Recurrent Kaposi sarcoma associated with Koebner phenomenon in two HIV-seronegative patients: Two case reports and a review of the literature

Dario Marino, Fiorella Calabrese, Giancarlo Ottaviano, Fabio Biagio La Torre, Mattia Vicario, Mauro Alaibac, Maria Luisa Calabrò

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Abstract

RATIONALE: Koebner phenomenon is occasionally reported in patients affected by classic Kaposi sarcoma (KS).

PATIENT CONCERNS: Here, we report 2 cases of KS associated with Koebner phenomenon and the correlation of human herpesvirus 8 molecular analysis with the clinical outcome.

INTERVENTIONS: In the first case, a patient with a history of sporadic cutaneous KS developed a recurrent lesion at the laryngeal tract, the site of a previous nodulectomy. In our second case, immunodeficiency induced by chemotherapy triggered the development of KS and Koebner phenomenon was limited to the skin at the site of safenectomy.

LESSONS: Our observations suggest that careful planning of surgical treatment is required in immunocompetent and immunocompromised patients with a medical history of KS. Moreover, mucosal sites (both respiratory and in the gastrointestinal tract) should be considered as potential sites for KS development.

Original languageEnglish
Pages (from-to)e9467
JournalMedicine
Volume96
Issue number52
DOIs
Publication statusPublished - Dec 2017

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Kaposi's Sarcoma
HIV
Human Herpesvirus 8
Skin
Immunocompromised Host
Gastrointestinal Tract
Drug Therapy

Keywords

  • Journal Article

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Recurrent Kaposi sarcoma associated with Koebner phenomenon in two HIV-seronegative patients : Two case reports and a review of the literature. / Marino, Dario; Calabrese, Fiorella; Ottaviano, Giancarlo; La Torre, Fabio Biagio; Vicario, Mattia; Alaibac, Mauro; Calabrò, Maria Luisa.

In: Medicine, Vol. 96, No. 52, 12.2017, p. e9467.

Research output: Contribution to journalArticle

Marino, Dario ; Calabrese, Fiorella ; Ottaviano, Giancarlo ; La Torre, Fabio Biagio ; Vicario, Mattia ; Alaibac, Mauro ; Calabrò, Maria Luisa. / Recurrent Kaposi sarcoma associated with Koebner phenomenon in two HIV-seronegative patients : Two case reports and a review of the literature. In: Medicine. 2017 ; Vol. 96, No. 52. pp. e9467.
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abstract = "RATIONALE: Koebner phenomenon is occasionally reported in patients affected by classic Kaposi sarcoma (KS).PATIENT CONCERNS: Here, we report 2 cases of KS associated with Koebner phenomenon and the correlation of human herpesvirus 8 molecular analysis with the clinical outcome.INTERVENTIONS: In the first case, a patient with a history of sporadic cutaneous KS developed a recurrent lesion at the laryngeal tract, the site of a previous nodulectomy. In our second case, immunodeficiency induced by chemotherapy triggered the development of KS and Koebner phenomenon was limited to the skin at the site of safenectomy.LESSONS: Our observations suggest that careful planning of surgical treatment is required in immunocompetent and immunocompromised patients with a medical history of KS. Moreover, mucosal sites (both respiratory and in the gastrointestinal tract) should be considered as potential sites for KS development.",
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T1 - Recurrent Kaposi sarcoma associated with Koebner phenomenon in two HIV-seronegative patients

T2 - Two case reports and a review of the literature

AU - Marino, Dario

AU - Calabrese, Fiorella

AU - Ottaviano, Giancarlo

AU - La Torre, Fabio Biagio

AU - Vicario, Mattia

AU - Alaibac, Mauro

AU - Calabrò, Maria Luisa

N1 - Copyright © 2017 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

PY - 2017/12

Y1 - 2017/12

N2 - RATIONALE: Koebner phenomenon is occasionally reported in patients affected by classic Kaposi sarcoma (KS).PATIENT CONCERNS: Here, we report 2 cases of KS associated with Koebner phenomenon and the correlation of human herpesvirus 8 molecular analysis with the clinical outcome.INTERVENTIONS: In the first case, a patient with a history of sporadic cutaneous KS developed a recurrent lesion at the laryngeal tract, the site of a previous nodulectomy. In our second case, immunodeficiency induced by chemotherapy triggered the development of KS and Koebner phenomenon was limited to the skin at the site of safenectomy.LESSONS: Our observations suggest that careful planning of surgical treatment is required in immunocompetent and immunocompromised patients with a medical history of KS. Moreover, mucosal sites (both respiratory and in the gastrointestinal tract) should be considered as potential sites for KS development.

AB - RATIONALE: Koebner phenomenon is occasionally reported in patients affected by classic Kaposi sarcoma (KS).PATIENT CONCERNS: Here, we report 2 cases of KS associated with Koebner phenomenon and the correlation of human herpesvirus 8 molecular analysis with the clinical outcome.INTERVENTIONS: In the first case, a patient with a history of sporadic cutaneous KS developed a recurrent lesion at the laryngeal tract, the site of a previous nodulectomy. In our second case, immunodeficiency induced by chemotherapy triggered the development of KS and Koebner phenomenon was limited to the skin at the site of safenectomy.LESSONS: Our observations suggest that careful planning of surgical treatment is required in immunocompetent and immunocompromised patients with a medical history of KS. Moreover, mucosal sites (both respiratory and in the gastrointestinal tract) should be considered as potential sites for KS development.

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