Recurrent leiomyosarcoma of the small bowel: A case series

Cecilia Ferrari, Stefano Di Domenico, Matteo Mascherini, Matteo Santoliquido, Luca Mastracci, Franco De Cian

Research output: Contribution to journalArticlepeer-review


Background/Aim: Leiomyosarcoma is an extremely rare, small bowel neoplasm (2% of all gastrointestinal tumours). Early diagnosis is challenging due to the slow growth of the cancer. The biological behaviour of this group of tumours is aggressive, and the first-line treatment is surgical resection. Patients and Methods: This is a report of 4 cases of small bowel leiomyosarcoma that were treated in the last ten years at Hospital San Martino: one involving the jejunum and three involving the ileum (age range=69-86 years). Three patients underwent surgical resection and one was treated with chemotherapy. Results: All patients who were eligible for surgery underwent radical resection with R0 margins. Mean overall survival was 33 months (range=8-84 months). Conclusion: Specific guidelines for small bowel leiomyosarcoma do not currently exist and these rare cases should be discussed in a multidisciplinary context. The first treatment approach is surgery, and in some cases, multivisceral resection may be needed to obtain free margins, even in recurrent cases.

Original languageEnglish
Pages (from-to)4199-4204
Number of pages6
JournalAnticancer Research
Issue number7
Publication statusPublished - Jul 2020


  • Leiomyosarcoma
  • Oncological surgery
  • Sarcoma
  • Small bowel

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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