Abstract
We report on a 10-year-old child with nephrotic syndrome who developed recurrent lymphomatoid papulosis (LYP) 60 months after the first episode of proteinuria. LYP appeared when the child was taking low-dose cyclosporin and disappeared after the drug was replaced by prednisone at doses utilized for nephrotic syndrome (2 mg/kg). During the tapering of steroids, when the child was treated with low-dose prednisone (0.2 mg/kg), both LYP and nephrotic syndrome started again and required the reintroduction of prednisone to restore a normal clinical situation. This is the first case of LYP occurring in concomitance and synchronous with nephrotic syndrome. LYP was unrelated to cyclosporin (second episode after its withdrawn) but preceded the recurrence of proteinuria, suggesting a relationship with the disease activity. Even though the etiology of LYP is, in this case, uncertain, it should be considered as a clinical association of nephrotic syndrome in children and also included among potential triggers of the disease.
| Original language | English |
|---|---|
| Pages (from-to) | 189-192 |
| Number of pages | 4 |
| Journal | Pediatric Nephrology |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Cyclosporin
- Lymphomatoid papulosis
- Nephrotic syndrome
ASJC Scopus subject areas
- Nephrology
- Pediatrics, Perinatology, and Child Health
Cite this
Recurrent lymphomatoid papulosis associated with nephrotic syndrome. An occurrence of uncertain origin. / Ghiggeri, Gian Marco; Bleid, Dario; Garaventa, Alberto; Coccia, Cristina; Gambini, Claudio; Caridi, Gianluca; Perfumo, Francesco.
In: Pediatric Nephrology, Vol. 24, No. 1, 2009, p. 189-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recurrent lymphomatoid papulosis associated with nephrotic syndrome. An occurrence of uncertain origin
AU - Ghiggeri, Gian Marco
AU - Bleid, Dario
AU - Garaventa, Alberto
AU - Coccia, Cristina
AU - Gambini, Claudio
AU - Caridi, Gianluca
AU - Perfumo, Francesco
PY - 2009
Y1 - 2009
N2 - We report on a 10-year-old child with nephrotic syndrome who developed recurrent lymphomatoid papulosis (LYP) 60 months after the first episode of proteinuria. LYP appeared when the child was taking low-dose cyclosporin and disappeared after the drug was replaced by prednisone at doses utilized for nephrotic syndrome (2 mg/kg). During the tapering of steroids, when the child was treated with low-dose prednisone (0.2 mg/kg), both LYP and nephrotic syndrome started again and required the reintroduction of prednisone to restore a normal clinical situation. This is the first case of LYP occurring in concomitance and synchronous with nephrotic syndrome. LYP was unrelated to cyclosporin (second episode after its withdrawn) but preceded the recurrence of proteinuria, suggesting a relationship with the disease activity. Even though the etiology of LYP is, in this case, uncertain, it should be considered as a clinical association of nephrotic syndrome in children and also included among potential triggers of the disease.
AB - We report on a 10-year-old child with nephrotic syndrome who developed recurrent lymphomatoid papulosis (LYP) 60 months after the first episode of proteinuria. LYP appeared when the child was taking low-dose cyclosporin and disappeared after the drug was replaced by prednisone at doses utilized for nephrotic syndrome (2 mg/kg). During the tapering of steroids, when the child was treated with low-dose prednisone (0.2 mg/kg), both LYP and nephrotic syndrome started again and required the reintroduction of prednisone to restore a normal clinical situation. This is the first case of LYP occurring in concomitance and synchronous with nephrotic syndrome. LYP was unrelated to cyclosporin (second episode after its withdrawn) but preceded the recurrence of proteinuria, suggesting a relationship with the disease activity. Even though the etiology of LYP is, in this case, uncertain, it should be considered as a clinical association of nephrotic syndrome in children and also included among potential triggers of the disease.
KW - Cyclosporin
KW - Lymphomatoid papulosis
KW - Nephrotic syndrome
UR - http://www.scopus.com/inward/record.url?scp=59849095120&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=59849095120&partnerID=8YFLogxK
U2 - 10.1007/s00467-007-0667-z
DO - 10.1007/s00467-007-0667-z
M3 - Article
C2 - 18026996
AN - SCOPUS:59849095120
VL - 24
SP - 189
EP - 192
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 1
ER -