Abstract
Problem: To investigate the possible relationship between human papillomavirus (HPV) infection and recurrent miscarriage (RM). Methods: In this retrospective case-control study, 49 women with unexplained RM (Group 1 - cases) and 475 women without any miscarriage and with at least one pregnancy at term (Group 2 - controls) were checked for cervical HPV infection through Hybrid Capture® II (HC 2) or polymerase chain reaction (PCR). Results: HPV+ DNA tests were detected in 13 (26.53%) RM women and in 294 (61.89%) control women (P <0.001). The prevalence rate in HPV+DNA tests was significantly different in the 30-39 years age range. No differences between groups were detected in HPV types, nor in the cytological and histological findings. Conclusion: Women with RM have a lower prevalence of HPV+DNA tests than controls. This suggests that immune reactivity potentially leading to RM could be in some way protective against genital HPV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 343-346 |
| Number of pages | 4 |
| Journal | American Journal of Reproductive Immunology |
| Volume | 70 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Nov 2013 |
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Keywords
- Cervical infection
- Human papillomavirus
- Recurrent miscarriage
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Obstetrics and Gynaecology
- Reproductive Medicine
Cite this
Recurrent miscarriage and cervical human papillomavirus infection. / Ticconi, Carlo; Pietropolli, Adalgisa; Fabbri, Guido; Capogna, Maria Vittoria; Perno, Carlo Federico; Piccione, Emilio.
In: American Journal of Reproductive Immunology, Vol. 70, No. 5, 11.2013, p. 343-346.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recurrent miscarriage and cervical human papillomavirus infection
AU - Ticconi, Carlo
AU - Pietropolli, Adalgisa
AU - Fabbri, Guido
AU - Capogna, Maria Vittoria
AU - Perno, Carlo Federico
AU - Piccione, Emilio
PY - 2013/11
Y1 - 2013/11
N2 - Problem: To investigate the possible relationship between human papillomavirus (HPV) infection and recurrent miscarriage (RM). Methods: In this retrospective case-control study, 49 women with unexplained RM (Group 1 - cases) and 475 women without any miscarriage and with at least one pregnancy at term (Group 2 - controls) were checked for cervical HPV infection through Hybrid Capture® II (HC 2) or polymerase chain reaction (PCR). Results: HPV+ DNA tests were detected in 13 (26.53%) RM women and in 294 (61.89%) control women (P <0.001). The prevalence rate in HPV+DNA tests was significantly different in the 30-39 years age range. No differences between groups were detected in HPV types, nor in the cytological and histological findings. Conclusion: Women with RM have a lower prevalence of HPV+DNA tests than controls. This suggests that immune reactivity potentially leading to RM could be in some way protective against genital HPV infection.
AB - Problem: To investigate the possible relationship between human papillomavirus (HPV) infection and recurrent miscarriage (RM). Methods: In this retrospective case-control study, 49 women with unexplained RM (Group 1 - cases) and 475 women without any miscarriage and with at least one pregnancy at term (Group 2 - controls) were checked for cervical HPV infection through Hybrid Capture® II (HC 2) or polymerase chain reaction (PCR). Results: HPV+ DNA tests were detected in 13 (26.53%) RM women and in 294 (61.89%) control women (P <0.001). The prevalence rate in HPV+DNA tests was significantly different in the 30-39 years age range. No differences between groups were detected in HPV types, nor in the cytological and histological findings. Conclusion: Women with RM have a lower prevalence of HPV+DNA tests than controls. This suggests that immune reactivity potentially leading to RM could be in some way protective against genital HPV infection.
KW - Cervical infection
KW - Human papillomavirus
KW - Recurrent miscarriage
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U2 - 10.1111/aji.12156
DO - 10.1111/aji.12156
M3 - Article
VL - 70
SP - 343
EP - 346
JO - American Journal of Reproductive Immunology and Microbiology
JF - American Journal of Reproductive Immunology and Microbiology
SN - 1046-7408
IS - 5
ER -