Recurrent miscarriage and cervical human papillomavirus infection

Carlo Ticconi, Adalgisa Pietropolli, Guido Fabbri, Maria Vittoria Capogna, Carlo Federico Perno, Emilio Piccione

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Problem: To investigate the possible relationship between human papillomavirus (HPV) infection and recurrent miscarriage (RM). Methods: In this retrospective case-control study, 49 women with unexplained RM (Group 1 - cases) and 475 women without any miscarriage and with at least one pregnancy at term (Group 2 - controls) were checked for cervical HPV infection through Hybrid Capture® II (HC 2) or polymerase chain reaction (PCR). Results: HPV+ DNA tests were detected in 13 (26.53%) RM women and in 294 (61.89%) control women (P <0.001). The prevalence rate in HPV+DNA tests was significantly different in the 30-39 years age range. No differences between groups were detected in HPV types, nor in the cytological and histological findings. Conclusion: Women with RM have a lower prevalence of HPV+DNA tests than controls. This suggests that immune reactivity potentially leading to RM could be in some way protective against genital HPV infection.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalAmerican Journal of Reproductive Immunology
Volume70
Issue number5
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Habitual Abortion
Papillomavirus Infections
Human Papillomavirus DNA Tests
Spontaneous Abortion
Case-Control Studies
Pregnancy
Polymerase Chain Reaction
Control Groups

Keywords

  • Cervical infection
  • Human papillomavirus
  • Recurrent miscarriage

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Recurrent miscarriage and cervical human papillomavirus infection. / Ticconi, Carlo; Pietropolli, Adalgisa; Fabbri, Guido; Capogna, Maria Vittoria; Perno, Carlo Federico; Piccione, Emilio.

In: American Journal of Reproductive Immunology, Vol. 70, No. 5, 11.2013, p. 343-346.

Research output: Contribution to journalArticle

Ticconi, C, Pietropolli, A, Fabbri, G, Capogna, MV, Perno, CF & Piccione, E 2013, 'Recurrent miscarriage and cervical human papillomavirus infection', American Journal of Reproductive Immunology, vol. 70, no. 5, pp. 343-346. https://doi.org/10.1111/aji.12156
Ticconi, Carlo ; Pietropolli, Adalgisa ; Fabbri, Guido ; Capogna, Maria Vittoria ; Perno, Carlo Federico ; Piccione, Emilio. / Recurrent miscarriage and cervical human papillomavirus infection. In: American Journal of Reproductive Immunology. 2013 ; Vol. 70, No. 5. pp. 343-346.
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