Recurrent miscarriage and cervical human papillomavirus infection

Carlo Ticconi, Adalgisa Pietropolli, Guido Fabbri, Maria Vittoria Capogna, Carlo Federico Perno, Emilio Piccione

Research output: Contribution to journalArticlepeer-review


Problem: To investigate the possible relationship between human papillomavirus (HPV) infection and recurrent miscarriage (RM). Methods: In this retrospective case-control study, 49 women with unexplained RM (Group 1 - cases) and 475 women without any miscarriage and with at least one pregnancy at term (Group 2 - controls) were checked for cervical HPV infection through Hybrid Capture® II (HC 2) or polymerase chain reaction (PCR). Results: HPV+ DNA tests were detected in 13 (26.53%) RM women and in 294 (61.89%) control women (P <0.001). The prevalence rate in HPV+DNA tests was significantly different in the 30-39 years age range. No differences between groups were detected in HPV types, nor in the cytological and histological findings. Conclusion: Women with RM have a lower prevalence of HPV+DNA tests than controls. This suggests that immune reactivity potentially leading to RM could be in some way protective against genital HPV infection.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalAmerican Journal of Reproductive Immunology
Issue number5
Publication statusPublished - Nov 2013


  • Cervical infection
  • Human papillomavirus
  • Recurrent miscarriage

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Obstetrics and Gynaecology
  • Reproductive Medicine


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