Recurrent mutations refine prognosis in chronic lymphocytic leukemia

P. Baliakas, A. Hadzidimitriou, L. A. Sutton, D. Rossi, E. Minga, N. Villamor, M. Larrayoz, J. Kminkova, A. Agathangelidis, Z. Davis, E. Tausch, E. Stalika, B. Kantorova, L. Mansouri, L. Scarfò, D. Cortese, V. Navrkalova, M. J J Rose-Zerilli, K. E. Smedby, G. JuliussonA. Anagnostopoulos, A. M. Makris, A. Navarro, J. Delgado, D. Oscier, C. Belessi, S. Stilgenbauer, P. Ghia, S. Pospisilova, G. Gaidano, E. Campo, J. C. Strefford, K. Stamatopoulos, R. Rosenquist

Research output: Contribution to journalArticle

Abstract

Through the European Research Initiative on chronic lymphocytic leukemia (CLL) (ERIC), we screened 3490 patients with CLL for mutations within the NOTCH1 (n=3334), SF3B1 (n=2322), TP53 (n=2309), MYD88 (n=1080) and BIRC3 (n=919) genes, mainly at diagnosis (75%) and before treatment (>90%). BIRC3 mutations (2.5%) were associated with unmutated IGHV genes (U-CLL), del(11q) and trisomy 12, whereas MYD88 mutations (2.2%) were exclusively found among M-CLL. NOTCH1, SF3B1 and TP53 exhibited variable frequencies and were mostly enriched within clinically aggressive cases. Interestingly, as the timespan between diagnosis and mutational screening increased, so too did the incidence of SF3B1 mutations; no such increase was observed for NOTCH1 mutations. Regarding the clinical impact, NOTCH1 mutations, SF3B1 mutations and TP53 aberrations (deletion/mutation, TP53ab) correlated with shorter time-to-first-treatment (P

Original languageEnglish
Pages (from-to)329-336
Number of pages8
JournalLeukemia
Volume29
Issue number2
DOIs
Publication statusPublished - Feb 7 2015

ASJC Scopus subject areas

  • Hematology
  • Cancer Research
  • Anesthesiology and Pain Medicine
  • Medicine(all)

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    Baliakas, P., Hadzidimitriou, A., Sutton, L. A., Rossi, D., Minga, E., Villamor, N., Larrayoz, M., Kminkova, J., Agathangelidis, A., Davis, Z., Tausch, E., Stalika, E., Kantorova, B., Mansouri, L., Scarfò, L., Cortese, D., Navrkalova, V., Rose-Zerilli, M. J. J., Smedby, K. E., ... Rosenquist, R. (2015). Recurrent mutations refine prognosis in chronic lymphocytic leukemia. Leukemia, 29(2), 329-336. https://doi.org/10.1038/leu.2014.196