Recurrent necroinflammatory disease of multiple organs and colon systemic presentation of inflammatory bowel disease or gut involvement during systemic disorder

G. C. Actis, A. Ottobrelli, B. Lavezzo, V. Modena, D. Regge, A. Veltri, C. Tomasini, P. Puiatti, D. Novero, G. Verme

Research output: Contribution to journalArticle


A 30-year-old man with a recurrent febrile illness resembling infection is described. Because he presented with an acute abdomen, he underwent a laparotomy, which showed the paraaortic and mesenteric lymph nodes to be changed into an abscess like granulomatous tissue made up of necrotized granulocytes. During further flare-ups, the disease affected the spleen, skin, colon, peripheral nerve, and muscle. Histology on the biopsy materials of both the skin and colon, and on the surgically removed spleen showed the same invading pathologic tissue. Exhaustive investigation disclosed no pathogen, and the flare-ups responded repeatedly to high-dose steroids. This patient's picture has recently been defined as a syndrome of chronic granulomatosis based on several published cases. As a distinctive feature, in pur patient the granulomas affected also the colon. For the present, and for another previously described similar case we analyzed the factors that might permit the differential diagnosis between the above-mentioned granulomatous syndrome and Crohn's colitis.

Original languageEnglish
Pages (from-to)2100-2105
Number of pages6
JournalDigestive Diseases and Sciences
Issue number10
Publication statusPublished - 1996



  • Chronic granulomatous syndrome
  • Crohn's disease
  • Inflammatory bowel disease
  • Sterile abscess
  • Systemic granulomatosis

ASJC Scopus subject areas

  • Gastroenterology

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