TY - JOUR
T1 - Recurrent pericarditis in children and adolescents
T2 - A multicentre cohort study
AU - Imazio, Massimo
AU - Brucato, Antonio
AU - Pluymaekers, Nikki
AU - Breda, Luciana
AU - Calabri, Giovanni
AU - Cantarini, Luca
AU - Cimaz, Rolando
AU - Colimodio, Filomena
AU - Corona, Fabrizia
AU - Cumetti, Davide
AU - Di Blasi Lo Cuccio, Chiara
AU - Gattorno, Marco
AU - Insalaco, Antonella
AU - Limongelli, Giuseppe
AU - Russo, Maria Giovanna
AU - Valenti, Anna
AU - Finkelstein, Yaron
AU - Martini, Alberto
PY - 2016
Y1 - 2016
N2 - Objective: Limited data are available about recurrent pericarditis in children. We sought to explore contemporary causes, characteristics, therapies and outcomes of recurrent pericarditis in paediatric patients. Methods: A multicentre (eight sites) cohort study of 110 consecutive cases of paediatric patients with at least two recurrences of pericarditis over an 11-year period (2000-2010) [median 13 years, interquartile range (IQR) 5, 69 boys]. Results: Recurrences were idiopathic or viral in 89.1% of cases, followed by postpericardiotomy syndrome (9.1%) and familial Mediterranean fever (0.9%). Recurrent pericarditis was treated with nonsteroidal anti-inflammatory drugs (NSAIDs) in 80.9% of cases, corticosteroids in 64.8% and colchicine was added in 61.8%. Immunosuppressive therapies were administered in 15.5% of patients after subsequent recurrences. After a median follow-up of 60th months, 528 subsequent recurrences were recorded (median 3, range 2-25). Corticosteroid-treated patients experienced more recurrences (standardized risk of recurrence per 100 person-years was 93.2 for patients treated with corticosteroids and 45.2 for those without), side effects and disease-related hospitalizations (for all P
AB - Objective: Limited data are available about recurrent pericarditis in children. We sought to explore contemporary causes, characteristics, therapies and outcomes of recurrent pericarditis in paediatric patients. Methods: A multicentre (eight sites) cohort study of 110 consecutive cases of paediatric patients with at least two recurrences of pericarditis over an 11-year period (2000-2010) [median 13 years, interquartile range (IQR) 5, 69 boys]. Results: Recurrences were idiopathic or viral in 89.1% of cases, followed by postpericardiotomy syndrome (9.1%) and familial Mediterranean fever (0.9%). Recurrent pericarditis was treated with nonsteroidal anti-inflammatory drugs (NSAIDs) in 80.9% of cases, corticosteroids in 64.8% and colchicine was added in 61.8%. Immunosuppressive therapies were administered in 15.5% of patients after subsequent recurrences. After a median follow-up of 60th months, 528 subsequent recurrences were recorded (median 3, range 2-25). Corticosteroid-treated patients experienced more recurrences (standardized risk of recurrence per 100 person-years was 93.2 for patients treated with corticosteroids and 45.2 for those without), side effects and disease-related hospitalizations (for all P
KW - Children
KW - Corticosteroids
KW - Pericarditis
KW - Prognosis
KW - Recurrent pericarditis
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U2 - 10.2459/JCM.0000000000000300
DO - 10.2459/JCM.0000000000000300
M3 - Article
AN - SCOPUS:84981187172
VL - 17
SP - 707
EP - 712
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
SN - 1558-2027
IS - 9
ER -