Recurrent pericarditis in children and adolescents: A multicentre cohort study

Massimo Imazio, A. L. Brucato, Nikki Pluymaekers, L. Breda, G. B. Calabri, L. Cantarini, Rolando Cimaz, Filomena Colimodio, Fabrizia Corona, Davide Cumetti, Chiara Di Blasi Lo Cuccio, Marco Gattorno, Antonella Insalaco, Giuseppe Limongelli, Maria Giovanna Russo, A. Valenti, Yaron Finkelstein, Alberto Martini

Research output: Contribution to journalArticle

Abstract

Objective: Limited data are available about recurrent pericarditis in children. We sought to explore contemporary causes, characteristics, therapies and outcomes of recurrent pericarditis in paediatric patients. Methods: A multicentre (eight sites) cohort study of 110 consecutive cases of paediatric patients with at least two recurrences of pericarditis over an 11-year period (2000-2010) [median 13 years, interquartile range (IQR) 5, 69 boys]. Results: Recurrences were idiopathic or viral in 89.1% of cases, followed by postpericardiotomy syndrome (9.1%) and familial Mediterranean fever (0.9%). Recurrent pericarditis was treated with nonsteroidal anti-inflammatory drugs (NSAIDs) in 80.9% of cases, corticosteroids in 64.8% and colchicine was added in 61.8%. Immunosuppressive therapies were administered in 15.5% of patients after subsequent recurrences. After a median follow-up of 60th months, 528 subsequent recurrences were recorded (median 3, range 2-25). Corticosteroid-treated patients experienced more recurrences (standardized risk of recurrence per 100 person-years was 93.2 for patients treated with corticosteroids and 45.2 for those without), side effects and disease-related hospitalizations (for all P

Original languageEnglish
Pages (from-to)707-712
Number of pages6
JournalJournal of Cardiovascular Medicine
Volume17
Issue number9
DOIs
Publication statusPublished - 2016

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Pericarditis
Multicenter Studies
Cohort Studies
Recurrence
Adrenal Cortex Hormones
Postpericardiotomy Syndrome
Pediatrics
Familial Mediterranean Fever
Colchicine
Immunosuppressive Agents
Hospitalization
Anti-Inflammatory Agents
Therapeutics
Pharmaceutical Preparations

Keywords

  • Children
  • Corticosteroids
  • Pericarditis
  • Prognosis
  • Recurrent pericarditis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Recurrent pericarditis in children and adolescents : A multicentre cohort study. / Imazio, Massimo; Brucato, A. L.; Pluymaekers, Nikki; Breda, L.; Calabri, G. B.; Cantarini, L.; Cimaz, Rolando; Colimodio, Filomena; Corona, Fabrizia; Cumetti, Davide; Di Blasi Lo Cuccio, Chiara; Gattorno, Marco; Insalaco, Antonella; Limongelli, Giuseppe; Russo, Maria Giovanna; Valenti, A.; Finkelstein, Yaron; Martini, Alberto.

In: Journal of Cardiovascular Medicine, Vol. 17, No. 9, 2016, p. 707-712.

Research output: Contribution to journalArticle

Imazio, M, Brucato, AL, Pluymaekers, N, Breda, L, Calabri, GB, Cantarini, L, Cimaz, R, Colimodio, F, Corona, F, Cumetti, D, Di Blasi Lo Cuccio, C, Gattorno, M, Insalaco, A, Limongelli, G, Russo, MG, Valenti, A, Finkelstein, Y & Martini, A 2016, 'Recurrent pericarditis in children and adolescents: A multicentre cohort study', Journal of Cardiovascular Medicine, vol. 17, no. 9, pp. 707-712. https://doi.org/10.2459/JCM.0000000000000300
Imazio, Massimo ; Brucato, A. L. ; Pluymaekers, Nikki ; Breda, L. ; Calabri, G. B. ; Cantarini, L. ; Cimaz, Rolando ; Colimodio, Filomena ; Corona, Fabrizia ; Cumetti, Davide ; Di Blasi Lo Cuccio, Chiara ; Gattorno, Marco ; Insalaco, Antonella ; Limongelli, Giuseppe ; Russo, Maria Giovanna ; Valenti, A. ; Finkelstein, Yaron ; Martini, Alberto. / Recurrent pericarditis in children and adolescents : A multicentre cohort study. In: Journal of Cardiovascular Medicine. 2016 ; Vol. 17, No. 9. pp. 707-712.
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