Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa

Anna Beltrame, Sergio Venturini, Giovanni Crichiutti, Valeria Meroni, Dora Buonfrate, Matteo Bassetti

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: We report an unusual case of acute acquired toxoplasmosis (AAT) presenting as lymphadenopathy and recurrent seizures in an immunocompetent 15-year-old boy. Materials and methods: The patient reported an 18-day vacation to Africa (Ethiopia), 39 days prior to the first seizure. Electroencephalogram (EEG) showed sporadic single-spike or sharp-wave paroxysms and the magnetic resonance imaging (RMI) of the brain was negative. The serology for T. gondii was compatible with an acute infection defined as positive for both toxoplasma-specific IgG and IgM and a low avidity (6 %), confirmed by a reference laboratory. The patient reported other two episodes of seizures, occurring 7 days apart. He was treated with pyrimethamine plus sulfadiazine and leucovorin for 4 weeks, with an improvement of lymphadenitis and normalization of EEG. After 5 months, new seizures were reported and a diagnosis of epilepsy was done. Toxoplasma polymerase chain reaction (PCR) of cerebrospinal fluid (CSF) and blood were negative. A treatment with valproic acid was started, obtaining control of the neurological disease. Conclusion: Awareness of this neurologic manifestation by clinicians is required, also in immunocompetent patients. The relationship between toxoplasmosis and recurrent seizure needs to be investigated by new studies.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalInfection
Volume44
Issue number2
DOIs
Publication statusPublished - Apr 1 2016

Keywords

  • Acute acquired toxoplasmosis
  • Immunocompetent
  • Seizure
  • Toxoplasma gondii
  • Travel

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa'. Together they form a unique fingerprint.

Cite this