Recurrent thrombosis in patients with polycythemia vera and essential thrombocythemia: Incidence, risk factors, and effect of treatments

Valerio De Stefano, Tommaso Za, Elena Rossi, Alessandro M. Vannucchi, Marco Ruggeri, Elena Elli, Caterina Micò, Alessia Tieghi, Rossella R. Cacciola, Cristina Santoro, Giancarla Gerli, Nicola Vianelli, Paola Guglielmelli, Lisa Pieri, Francesca Scognamiglio, Francesco Rodeghiero, Enrico M. Pogliani, Guido Finazzi, Luigi Gugliotta, Roberto MarchioliGiuseppe Leone, Tiziano Barbui

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Prior thrombosis is a well-established risk factor for re-thrombosis in polycythemia vera and essential thrombocythemia but scarce data are available on the rate of re-thrombosis and the optimal strategy for prevention of recurrence. Design and Methods: We retrospectively estimated the rate of recurrence in a multicenter cohort of 494 patients (polycythemia vera/essential thrombocythemia 235/259) with previous arterial (67.6%) or venous thrombosis (31%) or both (1.4%). First thrombosis was cerebrovascular disease in 191 cases, acute coronary syndrome in 106, peripheral arterial thrombosis in 44, and venous thromboembolism in 160. Microcirculatory events were not computed. Results: Thrombosis recurred in 166 patients (33.6%), with an incidence of 7.6% patient-years. Sex, diagnosis (polycythemia vera or essential thrombocythemia), and presence of vascular risk factors did not predict recurrence, whereas age >60 years did (multivariable hazard ratio [HR], 1.67; 95% confidence interval [CI] 1.19-2.32). Increased leukocyte count at the time of the first thrombosis was a risk factor for recurrence in patients

Original languageEnglish
Pages (from-to)372-380
Number of pages9
JournalHaematologica
Volume93
Issue number3
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Antiplatelet treatment
  • Cytoreductive treatment
  • Essential thrombocythemia
  • Oral anticoagulant treatment
  • Polycythemia vera
  • Recurrent thrombosis

ASJC Scopus subject areas

  • Hematology

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