TY - JOUR
T1 - Recurrent thrombosis in patients with polycythemia vera and essential thrombocythemia
T2 - Incidence, risk factors, and effect of treatments
AU - De Stefano, Valerio
AU - Za, Tommaso
AU - Rossi, Elena
AU - Vannucchi, Alessandro M.
AU - Ruggeri, Marco
AU - Elli, Elena
AU - Micò, Caterina
AU - Tieghi, Alessia
AU - Cacciola, Rossella R.
AU - Santoro, Cristina
AU - Gerli, Giancarla
AU - Vianelli, Nicola
AU - Guglielmelli, Paola
AU - Pieri, Lisa
AU - Scognamiglio, Francesca
AU - Rodeghiero, Francesco
AU - Pogliani, Enrico M.
AU - Finazzi, Guido
AU - Gugliotta, Luigi
AU - Marchioli, Roberto
AU - Leone, Giuseppe
AU - Barbui, Tiziano
PY - 2008/3
Y1 - 2008/3
N2 - Background: Prior thrombosis is a well-established risk factor for re-thrombosis in polycythemia vera and essential thrombocythemia but scarce data are available on the rate of re-thrombosis and the optimal strategy for prevention of recurrence. Design and Methods: We retrospectively estimated the rate of recurrence in a multicenter cohort of 494 patients (polycythemia vera/essential thrombocythemia 235/259) with previous arterial (67.6%) or venous thrombosis (31%) or both (1.4%). First thrombosis was cerebrovascular disease in 191 cases, acute coronary syndrome in 106, peripheral arterial thrombosis in 44, and venous thromboembolism in 160. Microcirculatory events were not computed. Results: Thrombosis recurred in 166 patients (33.6%), with an incidence of 7.6% patient-years. Sex, diagnosis (polycythemia vera or essential thrombocythemia), and presence of vascular risk factors did not predict recurrence, whereas age >60 years did (multivariable hazard ratio [HR], 1.67; 95% confidence interval [CI] 1.19-2.32). Increased leukocyte count at the time of the first thrombosis was a risk factor for recurrence in patients
AB - Background: Prior thrombosis is a well-established risk factor for re-thrombosis in polycythemia vera and essential thrombocythemia but scarce data are available on the rate of re-thrombosis and the optimal strategy for prevention of recurrence. Design and Methods: We retrospectively estimated the rate of recurrence in a multicenter cohort of 494 patients (polycythemia vera/essential thrombocythemia 235/259) with previous arterial (67.6%) or venous thrombosis (31%) or both (1.4%). First thrombosis was cerebrovascular disease in 191 cases, acute coronary syndrome in 106, peripheral arterial thrombosis in 44, and venous thromboembolism in 160. Microcirculatory events were not computed. Results: Thrombosis recurred in 166 patients (33.6%), with an incidence of 7.6% patient-years. Sex, diagnosis (polycythemia vera or essential thrombocythemia), and presence of vascular risk factors did not predict recurrence, whereas age >60 years did (multivariable hazard ratio [HR], 1.67; 95% confidence interval [CI] 1.19-2.32). Increased leukocyte count at the time of the first thrombosis was a risk factor for recurrence in patients
KW - Antiplatelet treatment
KW - Cytoreductive treatment
KW - Essential thrombocythemia
KW - Oral anticoagulant treatment
KW - Polycythemia vera
KW - Recurrent thrombosis
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U2 - 10.3324/haematol.12053
DO - 10.3324/haematol.12053
M3 - Article
C2 - 18268279
AN - SCOPUS:40849085151
VL - 93
SP - 372
EP - 380
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 3
ER -