Abstract
Triploidy is the most frequent chromosome aberration in first trimester spontaneous abortions. In contrast to aneuploidies due to nondisjunction, increased maternal age is not a risk factor and the mechanism of triploidy remains poorly understood. To date, recurrence of triploidy of maternal origin has been described only in a few families suggesting some underlying genetic factors. Here, we report on a woman who underwent three consecutive triploid pregnancies, in two of which maternal origin of triploidy was proved by molecular analysis.
| Original language | English |
|---|---|
| Pages (from-to) | 972-974 |
| Number of pages | 3 |
| Journal | European Journal of Human Genetics |
| Volume | 11 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2003 |
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Keywords
- Digyny
- Recurrent abortion
- Triploidy
ASJC Scopus subject areas
- Genetics(clinical)
Cite this
Recurrent triploidy of maternal origin. / Brancati, Francesco; Mingarelli, Rita; Dallapiccola, Bruno.
In: European Journal of Human Genetics, Vol. 11, No. 12, 12.2003, p. 972-974.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recurrent triploidy of maternal origin
AU - Brancati, Francesco
AU - Mingarelli, Rita
AU - Dallapiccola, Bruno
PY - 2003/12
Y1 - 2003/12
N2 - Triploidy is the most frequent chromosome aberration in first trimester spontaneous abortions. In contrast to aneuploidies due to nondisjunction, increased maternal age is not a risk factor and the mechanism of triploidy remains poorly understood. To date, recurrence of triploidy of maternal origin has been described only in a few families suggesting some underlying genetic factors. Here, we report on a woman who underwent three consecutive triploid pregnancies, in two of which maternal origin of triploidy was proved by molecular analysis.
AB - Triploidy is the most frequent chromosome aberration in first trimester spontaneous abortions. In contrast to aneuploidies due to nondisjunction, increased maternal age is not a risk factor and the mechanism of triploidy remains poorly understood. To date, recurrence of triploidy of maternal origin has been described only in a few families suggesting some underlying genetic factors. Here, we report on a woman who underwent three consecutive triploid pregnancies, in two of which maternal origin of triploidy was proved by molecular analysis.
KW - Digyny
KW - Recurrent abortion
KW - Triploidy
UR - http://www.scopus.com/inward/record.url?scp=0346656817&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0346656817&partnerID=8YFLogxK
U2 - 10.1038/sj.ejhg.5201076
DO - 10.1038/sj.ejhg.5201076
M3 - Article
VL - 11
SP - 972
EP - 974
JO - European Journal of Human Genetics
JF - European Journal of Human Genetics
SN - 1018-4813
IS - 12
ER -