Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use

Ida Martinelli; Anthonie W A Lensing; Saskia Middeldorp; Marcel Levi; Jan Beyer-Westendorf; Bonno Van Bellen; Henri Bounameaux; Timothy A. Brighton; Alexander T. Cohen; Mila Trajanovic; Martin Gebel; Phuong Lam; Philip S. Wells; Martin H. Prins

doi:10.1182/blood-2015-08-665927

Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use

Ida Martinelli, Anthonie W A Lensing, Saskia Middeldorp, Marcel Levi, Jan Beyer-Westendorf, Bonno Van Bellen, Henri Bounameaux, Timothy A. Brighton, Alexander T. Cohen, Mila Trajanovic, Martin Gebel, Phuong Lam, Philip S. Wells, Martin H. Prins

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Women receiving vitamin K antagonists (VKAs) require adequate contraception because of the potential for fetal complications. It is unknown whether the use of hormonal therapy, especially those containing estrogens, is associated with recurrent venous thromboembolism (VTE) during anticoagulation. Despite the absence of data, World Health Organization guidelines state that use of estrogen-containing contraceptives confers an "unacceptable health risk" during established anticoagulation for VTE. We compared the incidences of recurrent VTE and abnormal uterine bleeding with and without concomitant hormonal therapy in women aged

Original language	English
Pages (from-to)	1417-1425
Number of pages	9
Journal	Blood
Volume	127
Issue number	11
DOIs	https://doi.org/10.1182/blood-2015-08-665927
Publication status	Published - Mar 17 2016

ASJC Scopus subject areas

Hematology
Biochemistry
Cell Biology
Immunology

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10.1182/blood-2015-08-665927

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Martinelli, I., Lensing, A. W. A., Middeldorp, S., Levi, M., Beyer-Westendorf, J., Bellen, B. V., Bounameaux, H., Brighton, T. A., Cohen, A. T., Trajanovic, M., Gebel, M., Lam, P., Wells, P. S., & Prins, M. H. (2016). Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use. Blood, 127(11), 1417-1425. https://doi.org/10.1182/blood-2015-08-665927

Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use. / Martinelli, Ida; Lensing, Anthonie W A; Middeldorp, Saskia; Levi, Marcel; Beyer-Westendorf, Jan; Bellen, Bonno Van; Bounameaux, Henri; Brighton, Timothy A.; Cohen, Alexander T.; Trajanovic, Mila; Gebel, Martin; Lam, Phuong; Wells, Philip S.; Prins, Martin H.

In: Blood, Vol. 127, No. 11, 17.03.2016, p. 1417-1425.

Research output: Contribution to journal › Article › peer-review

Martinelli, I, Lensing, AWA, Middeldorp, S, Levi, M, Beyer-Westendorf, J, Bellen, BV, Bounameaux, H, Brighton, TA, Cohen, AT, Trajanovic, M, Gebel, M, Lam, P, Wells, PS & Prins, MH 2016, 'Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use', Blood, vol. 127, no. 11, pp. 1417-1425. https://doi.org/10.1182/blood-2015-08-665927

Martinelli, Ida ; Lensing, Anthonie W A ; Middeldorp, Saskia ; Levi, Marcel ; Beyer-Westendorf, Jan ; Bellen, Bonno Van ; Bounameaux, Henri ; Brighton, Timothy A. ; Cohen, Alexander T. ; Trajanovic, Mila ; Gebel, Martin ; Lam, Phuong ; Wells, Philip S. ; Prins, Martin H. / Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use. In: Blood. 2016 ; Vol. 127, No. 11. pp. 1417-1425.

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Recurrent venous thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use

Abstract

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