TY - JOUR
T1 - Red blood cell copper, zinc superoxide dismutase activity is higher in Alzheimer's disease and is decreased by D-penicillamine
AU - Rossi, Luisa
AU - Squitti, Rosanna
AU - Pasqualetti, Patrizio
AU - Marchese, Eliana
AU - Cassetta, Emanuele
AU - Forastiere, Elisabetta
AU - Rotilio, Giuseppe
AU - Rossini, Paolo M.
AU - Finazzi-Agró, Alessandro
PY - 2002/8/30
Y1 - 2002/8/30
N2 - Copper, zinc superoxide dismutase (Cu, Zn SOD) activity was measured in red blood cells (RBC) of 32 patients affected by Alzheimer's disease (AD), eight other AD patients treated with the copper-chelating agent D-penicillamine, 13 first-degree relatives and 22 controls. All AD patients enrolled in our study showed a higher level of Cu, Zn SOD activity early in the disease. No correlation between apolipoprotein E genotype and SOD activity was found in AD patients. D-penicillamine treatment of AD patients for 24 weeks lowered the enzyme activity even below the control value. These results support the hypothesis that a higher level of Cu, Zn SOD activity in RBC can be an early diagnostic peripheral marker of this disease and a sensor to monitor treatments with copper-chelating drugs.
AB - Copper, zinc superoxide dismutase (Cu, Zn SOD) activity was measured in red blood cells (RBC) of 32 patients affected by Alzheimer's disease (AD), eight other AD patients treated with the copper-chelating agent D-penicillamine, 13 first-degree relatives and 22 controls. All AD patients enrolled in our study showed a higher level of Cu, Zn SOD activity early in the disease. No correlation between apolipoprotein E genotype and SOD activity was found in AD patients. D-penicillamine treatment of AD patients for 24 weeks lowered the enzyme activity even below the control value. These results support the hypothesis that a higher level of Cu, Zn SOD activity in RBC can be an early diagnostic peripheral marker of this disease and a sensor to monitor treatments with copper-chelating drugs.
KW - Alzheimer's disease
KW - Apolipoprotein E
KW - Copper
KW - Copper, zinc superoxide dismutase
KW - D-penicillamine
UR - http://www.scopus.com/inward/record.url?scp=0037199654&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037199654&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(02)00599-2
DO - 10.1016/S0304-3940(02)00599-2
M3 - Article
C2 - 12165396
AN - SCOPUS:0037199654
VL - 329
SP - 137
EP - 140
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -