TY - JOUR
T1 - Red blood cell sodium-lithium countertransport, blood pressure, and uric acid metabolism in untreated healthy men
AU - Strazzullo, Pasquale
AU - Cappuccio, Francesco P.
AU - Trevisan, Maurizio
AU - Iacoviello, Licia
AU - Iacone, Roberto
AU - Barba, Gianvincenzo
AU - Leo, Aniello De
AU - Parinaro, Eduardo
AU - Mancini, Mario
PY - 1989
Y1 - 1989
N2 - The relationship of red blood cell (RBC) Na/Li countertransport to the renal handling of lithium and uric acid was investigated in a sample of 176 untreated men. Subjects in the upper quintile of the Na/Li countertransport distribution (n = 40), compared to those in the two lower quintiles (n = 72), had higher serum uric acid levels (0.34 ± 0.06 ν 0.29 ± 0.05 mmol/L, P ` 0.001) and systolic blood pressure (131 ± 19 ν 123 ± 16 mm Hg, P ` 0.02) and slightly lower fractional excretion of uric acid (7.5 ± 1.5 ν 8.4 ± 2.6%, P ` 0.08). The lithium fractional excretion was not significantly related to either blood pressure or R B C Na/Li countertransport. The altered uric acid metabolism in individuals with high RBC Na/Li countertransport could be the expression of an abnormality of renal tubular function. Am J Hypertens 1989; 2: 634-636.
AB - The relationship of red blood cell (RBC) Na/Li countertransport to the renal handling of lithium and uric acid was investigated in a sample of 176 untreated men. Subjects in the upper quintile of the Na/Li countertransport distribution (n = 40), compared to those in the two lower quintiles (n = 72), had higher serum uric acid levels (0.34 ± 0.06 ν 0.29 ± 0.05 mmol/L, P ` 0.001) and systolic blood pressure (131 ± 19 ν 123 ± 16 mm Hg, P ` 0.02) and slightly lower fractional excretion of uric acid (7.5 ± 1.5 ν 8.4 ± 2.6%, P ` 0.08). The lithium fractional excretion was not significantly related to either blood pressure or R B C Na/Li countertransport. The altered uric acid metabolism in individuals with high RBC Na/Li countertransport could be the expression of an abnormality of renal tubular function. Am J Hypertens 1989; 2: 634-636.
KW - Blood pressure
KW - Lithium clearance
KW - Na/Li countertransport
KW - Uric acid metabolism
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U2 - 10.1093/ajh/2.8.634
DO - 10.1093/ajh/2.8.634
M3 - Article
C2 - 2775505
AN - SCOPUS:0024346466
VL - 2
SP - 634
EP - 636
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 8
ER -