Red blood cell sodium-lithium countertransport, blood pressure, and uric acid metabolism in untreated healthy men

Pasquale Strazzullo, Francesco P. Cappuccio, Maurizio Trevisan, Licia Iacoviello, Roberto Iacone, Gianvincenzo Barba, Aniello De Leo, Eduardo Parinaro, Mario Mancini

Research output: Contribution to journalArticlepeer-review

Abstract

The relationship of red blood cell (RBC) Na/Li countertransport to the renal handling of lithium and uric acid was investigated in a sample of 176 untreated men. Subjects in the upper quintile of the Na/Li countertransport distribution (n = 40), compared to those in the two lower quintiles (n = 72), had higher serum uric acid levels (0.34 ± 0.06 ν 0.29 ± 0.05 mmol/L, P ` 0.001) and systolic blood pressure (131 ± 19 ν 123 ± 16 mm Hg, P ` 0.02) and slightly lower fractional excretion of uric acid (7.5 ± 1.5 ν 8.4 ± 2.6%, P ` 0.08). The lithium fractional excretion was not significantly related to either blood pressure or R B C Na/Li countertransport. The altered uric acid metabolism in individuals with high RBC Na/Li countertransport could be the expression of an abnormality of renal tubular function. Am J Hypertens 1989; 2: 634-636.

Original languageEnglish
Pages (from-to)634-636
Number of pages3
JournalAmerican Journal of Hypertension
Volume2
Issue number8
DOIs
Publication statusPublished - 1989

Keywords

  • Blood pressure
  • Lithium clearance
  • Na/Li countertransport
  • Uric acid metabolism

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

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