Red cell aging and active calcium transport

Michele Samaja; Alessandro Rubinacci; Roberto Motterlini; Alessandro De Ponti; Nicola Portinaro

doi:10.1016/0531-5565(90)90063-8

Red cell aging and active calcium transport

Michele Samaja, Alessandro Rubinacci, Roberto Motterlini, Alessandro De Ponti, Nicola Portinaro

Research output: Contribution to journal › Article › peer-review

Abstract

The authors have investigated the relationships between the active calcium transport across the human red blood cell (RBC) membrane and the RBC aging processes in vivo and in vitro. For the study of this biological system, the authors have determined the active calcium uptake by inside-out membrane vesicles obtained from selected RBC populations. This model provided an optimal way to assess the biochemical and functional responses of the human cell to the oxidative stimulus triggered by the cellular aging processes. The activity of the calcium pump is indeed strictly correlated to the oxidative damage suffered by the RBC, being higher in the aged RBC. It appears that the main controller of the active calcium transport is the age-dependent protein inhibitor of the calcium pump.

Original language	English
Pages (from-to)	279-286
Number of pages	8
Journal	Experimental Gerontology
Volume	25
Issue number	3-4
DOIs	https://doi.org/10.1016/0531-5565(90)90063-8
Publication status	Published - 1990

Keywords

active calcium transport
calcium homeostasis
inside-out vesicles
oxidative damage
red cell aging
red cell density

ASJC Scopus subject areas

Ageing
Medicine(all)

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10.1016/0531-5565(90)90063-8

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title = "Red cell aging and active calcium transport",

abstract = "The authors have investigated the relationships between the active calcium transport across the human red blood cell (RBC) membrane and the RBC aging processes in vivo and in vitro. For the study of this biological system, the authors have determined the active calcium uptake by inside-out membrane vesicles obtained from selected RBC populations. This model provided an optimal way to assess the biochemical and functional responses of the human cell to the oxidative stimulus triggered by the cellular aging processes. The activity of the calcium pump is indeed strictly correlated to the oxidative damage suffered by the RBC, being higher in the aged RBC. It appears that the main controller of the active calcium transport is the age-dependent protein inhibitor of the calcium pump.",

keywords = "active calcium transport, calcium homeostasis, inside-out vesicles, oxidative damage, red cell aging, red cell density",

author = "Michele Samaja and Alessandro Rubinacci and Roberto Motterlini and {De Ponti}, Alessandro and Nicola Portinaro",

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journal = "Experimental Gerontology",

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T1 - Red cell aging and active calcium transport

AU - Samaja, Michele

AU - Rubinacci, Alessandro

AU - Motterlini, Roberto

AU - De Ponti, Alessandro

AU - Portinaro, Nicola

PY - 1990

Y1 - 1990

N2 - The authors have investigated the relationships between the active calcium transport across the human red blood cell (RBC) membrane and the RBC aging processes in vivo and in vitro. For the study of this biological system, the authors have determined the active calcium uptake by inside-out membrane vesicles obtained from selected RBC populations. This model provided an optimal way to assess the biochemical and functional responses of the human cell to the oxidative stimulus triggered by the cellular aging processes. The activity of the calcium pump is indeed strictly correlated to the oxidative damage suffered by the RBC, being higher in the aged RBC. It appears that the main controller of the active calcium transport is the age-dependent protein inhibitor of the calcium pump.

AB - The authors have investigated the relationships between the active calcium transport across the human red blood cell (RBC) membrane and the RBC aging processes in vivo and in vitro. For the study of this biological system, the authors have determined the active calcium uptake by inside-out membrane vesicles obtained from selected RBC populations. This model provided an optimal way to assess the biochemical and functional responses of the human cell to the oxidative stimulus triggered by the cellular aging processes. The activity of the calcium pump is indeed strictly correlated to the oxidative damage suffered by the RBC, being higher in the aged RBC. It appears that the main controller of the active calcium transport is the age-dependent protein inhibitor of the calcium pump.

KW - active calcium transport

KW - calcium homeostasis

KW - inside-out vesicles

KW - oxidative damage

KW - red cell aging

KW - red cell density

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Red cell aging and active calcium transport

Abstract

Keywords

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