Red cell aging and active calcium transport

Michele Samaja, Alessandro Rubinacci, Roberto Motterlini, Alessandro De Ponti, Nicola Portinaro

Research output: Contribution to journalArticlepeer-review

Abstract

The authors have investigated the relationships between the active calcium transport across the human red blood cell (RBC) membrane and the RBC aging processes in vivo and in vitro. For the study of this biological system, the authors have determined the active calcium uptake by inside-out membrane vesicles obtained from selected RBC populations. This model provided an optimal way to assess the biochemical and functional responses of the human cell to the oxidative stimulus triggered by the cellular aging processes. The activity of the calcium pump is indeed strictly correlated to the oxidative damage suffered by the RBC, being higher in the aged RBC. It appears that the main controller of the active calcium transport is the age-dependent protein inhibitor of the calcium pump.

Original languageEnglish
Pages (from-to)279-286
Number of pages8
JournalExperimental Gerontology
Volume25
Issue number3-4
DOIs
Publication statusPublished - 1990

Keywords

  • active calcium transport
  • calcium homeostasis
  • inside-out vesicles
  • oxidative damage
  • red cell aging
  • red cell density

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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