Red cell metabolism in anaemia: The oxygen uptake in the presence of methylene blue

S. Ferrone, A. Zanella, A. Flores, G. Sirchia

Research output: Contribution to journalArticlepeer-review

Abstract

The red cell oxygen uptake in the presence of methylene blue has been investigated in 248 cases of anaemia of different cause. An increased metabolic activity appeared to be an accompanying feature of anaemia; it was particularly higher than normal in autoimmune haemolytic anaemias, thalassaemias, iron-deficiency anaemia and chronic renal insufficiency. The pathogenesis of this finding is discussed and it is suggested that the metabolic abnormality occurs as a consequence of a decrease in the mean age of circulating erythrocytes and/or an unfavourable environment for red cell formation or survival.

Original languageEnglish
Pages (from-to)279-286
Number of pages8
JournalActa Haematologica
Volume44
Issue number5
DOIs
Publication statusPublished - 1970

ASJC Scopus subject areas

  • Hematology

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