Red grape polyphenol oral administration improves immune response in women affected by nickel-mediated allergic contact dermatitis

Thea Magrone, Emilio Jirillo, Manrico Magrone, Matteo A. Russo, Paolo Romita, Francesco Massari, Caterina Foti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Our previous findings demonstrated that in vitro supplementation of polyphenols, extracted from seeds of red grape (Nero di Troia cultivar), to peripheral lymphomonocytes from patients affected by allergic contact dermatitis (ACD) to nickel (Ni) could reduce the release of proinflammatory cytokines and nitric oxide (NO), while increasing the levels of interleukin (IL)-10, an anti-inflammatory cytokine. Objective: To assess whether an intervention with oral administration of polyphenols leads to a reduction of peripheral biomarkers in ACD patients. Methods: At T0, 25 patients affected by ACD to Ni were orally administered with 300 mg polyphenols prodie extracted from seeds of red grape (Nero di Troia cultivar) (NATUR-OX®) for 3 months (T1). The other 25 patients affected by ACD to Ni received placebo only for the same period of time. Serum biomarkers were analyzed at T0 and T1. In both groups, seven dropouts were recorded. Results: At T1 in comparison to T0, in treated patients, values of interferon-γ, IL-4, IL-17, pentraxin 3 and NO decreased, while IL-10 levels increased when compared with T0 values. Conversely, in placebo-treated patients, no modifications of biomarkers were evaluated at T1. Conclusion: Present laboratory data rely on the anti-oxidant, anti-inflammatory and anti-allergic properties of polyphenols.

Original languageEnglish
Pages (from-to)374-384
Number of pages11
JournalEndocrine, Metabolic and Immune Disorders - Drug Targets
Volume21
Issue number2
DOIs
Publication statusPublished - 2021

Keywords

  • Allergic contact dermatitis
  • Cellular and molecular rehabilitation
  • Cytokines
  • Immune response
  • Nickel
  • Polyphenols

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy

Fingerprint

Dive into the research topics of 'Red grape polyphenol oral administration improves immune response in women affected by nickel-mediated allergic contact dermatitis'. Together they form a unique fingerprint.

Cite this