Red nucleus connectivity as revealed by constrained spherical deconvolution tractography

Demetrio Milardi, Alberto Cacciola, Giuseppina Cutroneo, Silvia Marino, Mariangela Irrera, Giorgio Cacciola, Giuseppe Santoro, Pietro Ciolli, Giuseppe Anastasi, Rocco Salvatore Calabrò, Angelo Quartarone

Research output: Contribution to journalArticlepeer-review


Previous Diffusion Tensor Imaging studies have demonstrated that the human red nucleus is widely interconnected with sensory-motor and prefrontal cortices.In this study, we assessed red nucleus connectivity by using a multi-tensor model called non- negative Constrained Spherical Deconvolution (CSD), which is able to resolve more than one fiber orientation per voxel.Connections of the red nuclei of fifteen volunteers were studied at 3 T using CSD axonal tracking.We found significant connectivity between RN and the following cortical and subcortical areas: cerebellar cortex, thalamus, paracentral lobule, postcentral gyrus, precentral gyrus, superior frontal gyrus and dentate nucleus.We confirmed that red nucleus is tightly linked with the cerebral cortex and has dense subcortical connections with thalamus and cerebellar cortex. These findings may be useful in a clinical context considering that RN is involved in motor control and it is known to have potential to compensate for injury of the corticospinal tract.

Original languageEnglish
Pages (from-to)68-73
Number of pages6
JournalNeuroscience Letters
Publication statusPublished - Jul 28 2016


  • Connectivity
  • CSD
  • Red nucleus
  • Tractography

ASJC Scopus subject areas

  • Neuroscience(all)


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