Redefining thalassemia as a hypercoagulable state

M. Domenica Cappellini; Irene Motta; Khaled M. Musallam; Ali T. Taher

doi:10.1111/j.1749-6632.2010.05548.x

Redefining thalassemia as a hypercoagulable state

M. Domenica Cappellini, Irene Motta, Khaled M. Musallam, Ali T. Taher

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.

Original language	English
Title of host publication	Annals of the New York Academy of Sciences
Pages	231-236
Number of pages	6
Volume	1202
DOIs	https://doi.org/10.1111/j.1749-6632.2010.05548.x
Publication status	Published - Aug 2010

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1202
ISSN (Print)	00778923
ISSN (Electronic)	17496632

Keywords

hypercoagulability
stroke
thalassemia
thromboembolism

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1111/j.1749-6632.2010.05548.x

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