Redefining thalassemia as a hypercoagulable state

M. Domenica Cappellini, Irene Motta, Khaled M. Musallam, Ali T. Taher

Research output: Chapter in Book/Report/Conference proceedingConference contribution


As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages6
Publication statusPublished - Aug 2010

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • hypercoagulability
  • stroke
  • thalassemia
  • thromboembolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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