TY - GEN
T1 - Redefining thalassemia as a hypercoagulable state
AU - Cappellini, M. Domenica
AU - Motta, Irene
AU - Musallam, Khaled M.
AU - Taher, Ali T.
PY - 2010/8
Y1 - 2010/8
N2 - As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.
AB - As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.
KW - hypercoagulability
KW - stroke
KW - thalassemia
KW - thromboembolism
UR - http://www.scopus.com/inward/record.url?scp=77955894491&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955894491&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2010.05548.x
DO - 10.1111/j.1749-6632.2010.05548.x
M3 - Conference contribution
C2 - 20712798
AN - SCOPUS:77955894491
SN - 9781573317825
VL - 1202
T3 - Annals of the New York Academy of Sciences
SP - 231
EP - 236
BT - Annals of the New York Academy of Sciences
ER -