Redefining thalassemia as a hypercoagulable state

M. Domenica Cappellini, Irene Motta, Khaled M. Musallam, Ali T. Taher

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

As the life expectancy of β-thalassemia patients has markedly improved over the last decade, several new complications are being recognized. The presence of a high incidence of thromboembolic events, mainly in thalassemia intermedia patients, has led to the identification of a hypercoagulable state in thalassemia. In this review, the molecular and cellular mechanisms leading to hypercoagulability in thalassemia are highlighted, and the current clinical experience is summarized. Recommendations for thrombosis prophylaxis are also discussed.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages231-236
Number of pages6
Volume1202
DOIs
Publication statusPublished - Aug 2010

Publication series

NameAnnals of the New York Academy of Sciences
Volume1202
ISSN (Print)00778923
ISSN (Electronic)17496632

Keywords

  • hypercoagulability
  • stroke
  • thalassemia
  • thromboembolism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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