Redirected T cells in cancer therapy

Research output: Contribution to journalArticle

Abstract

Genetic engineering of T lymphocytes is an appealing strategy to confer and enhance new antitumor specificities to generate effective anticancer cell products for adoptive immunotherapy. The two main approaches are based either on transgenic tumor-antigen specific T cell receptors (TCR) or chimeric antigen receptors (CAR). Initial clinical trials reported important results against selected diseases, along with relevant warnings. Ongoing research challenges are directed toward a widespread application of this approach enhancing the range of possible target antigens, antitumor activity and safety, but also addressing logistic issues regarding cost/effectiveness, up-scaled/automated production and compliance with regulations.

Original languageEnglish
JournalExpert Opinion on Biological Therapy
DOIs
Publication statusAccepted/In press - Oct 29 2015

Keywords

  • adoptive immunotherapy
  • CAR
  • engineered T cells
  • TCR

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Biochemistry
  • Drug Discovery

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