Redirecting the immune response: Role of adoptive T cell therapy

Anna Mondino, Valérie Dardalhon, Rodrigo Hess Michelini, Severine Loisel-Meyer, Naomi Taylor

Research output: Contribution to journalArticlepeer-review

Abstract

Adoptive T cell therapy is aimed at overcoming constraints of the endogenous immune response. In patients with malignancies, this approach is based on the possibility of administering sufficient numbers of tumor-reactive lymphocytes under conditions in which they will promote a therapeutic response. Although this strategy is potentially applicable to a vast number of malignancies, its efficacy, to date, has been limited. This is likely related to several factors including an insufficient persistence and reactivation of infused cells, insufficient tumor infiltration, and the presence of an immunosuppressive environment. Here, we review the importance of pretransplantation host conditioning and posttransplantation strategies that have been shown to contribute to the therapeutic efficacy of infused T lymphocytes.

Original languageEnglish
Pages (from-to)533-541
Number of pages9
JournalHuman Gene Therapy
Volume21
Issue number5
DOIs
Publication statusPublished - May 1 2010

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine

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