Redondovirus DNA in human respiratory samples

Pietro Giorgio Spezia, Lisa Macera, Paola Mazzetti, Michele Curcio, Chiara Biagini, Ilaria Sciandra, Ombretta Turriziani, Michele Lai, Guido Antonelli, Mauro Pistello, Fabrizio Maggi

Research output: Contribution to journalArticlepeer-review


Background: Redondovirus (ReDoV) is a recently discovered circular, Rep-encoding single-stranded DNA (CRESS-DNA) virus in humans. Its pathogenesis and clinical associations are still completely unknown. Methods: The presence of ReDoV DNA was investigated in biological specimens of 543 Italian subjects by in-house developed PCR assays. Results: The overall ReDoV prevalence was about 4% (23 of 543 samples). The virus was detected in 22 of 209 (11 %) respiratory samples. One stool sample was also ReDoV positive. Viral DNA was not found in blood samples from immunocompetent and immunosuppressed subjects and cerebrospinal fluids from patients with neurological diseases. Genomic nucleotide differences were detected among the ReDoV isolates by sequencing a 582-nucleotide fragment of the capsid gene of the viral genome. Conclusions: The results demonstrate that ReDoV is mainly present in the respiratory tract of infected people. Further investigations are needed to reveal possible clinical implications of this new CRESS-DNA virus in humans.

Original languageEnglish
Article number104586
JournalJournal of Clinical Virology
Publication statusPublished - Oct 2020


  • Human redondovirus
  • Real-time PCR
  • ReDoV DNA
  • Respiratory tract
  • Sequencing

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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