Redox imbalance in T cell-mediated skin diseases

Saveria Pastore, Liudmila Korkina

Research output: Contribution to journalArticle

Abstract

The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative stress. We will concentrate on the evidence that a local and/or systemic redox dysregulation accompanies the chronic inflammatory disorder events associated to psoriasis, contact dermatitis, and atopic dermatitis. We will also discuss the fact that several well-established treatments for the therapy of chronic inflammatory skin disorders are based on the application of strong physical or chemical oxidants onto the skin, indicating that, in selected conditions, a further increase of the oxidative imbalance may lead to a beneficial outcome.

Original languageEnglish
Article number861949
JournalMediators of Inflammation
Volume2010
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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