TY - JOUR
T1 - Redox imbalances in ageing and metabolic alterations
T2 - Implications in cancer and cardiac diseases. An overview from the working group of cardiotoxicity and cardioprotection of the Italian society of cardiology (SIC)
AU - Mercurio, Valentina
AU - Cuomo, Alessandra
AU - Dessalvi, Christian Cadeddu
AU - Deidda, Martino
AU - Di Lisi, Daniela
AU - Novo, Giuseppina
AU - Manganaro, Roberta
AU - Zito, Concetta
AU - Santoro, Ciro
AU - Ameri, Pietro
AU - Spallarossa, Paolo
AU - Arboscello, Eleonora
AU - Tocchetti, Carlo Gabriele
AU - Penna, Claudia
PY - 2020/7
Y1 - 2020/7
N2 - Metabolic syndrome (MetS) is a well established risk factor for cardiovascular (CV) diseases. In addition, several studies indicate that MetS correlates with the increased risk of cancer in adults. The mechanisms linking MetS and cancer are not fully understood. Several risk factors involved in MetS are also cancer risk factors, such as the consumption of high calorie-food or high fat intake, low fibre intake, and sedentary lifestyle. Other common aspects of both cancer and MetS are oxidative stress and inflammation. In addition, some anticancer treatments can induce cardiotoxicity, including, for instance, left ventricular (LV) dysfunction and heart failure (HF), endothelial dysfunction and hypertension. In this review, we analyse several aspects of MetS, cancer and cardiotoxicity from anticancer drugs. In particular, we focus on oxidative stress in ageing, cancer and CV diseases, and we analyse the connections among CV risk factors, cancer and cardiotoxicity from anticancer drugs.
AB - Metabolic syndrome (MetS) is a well established risk factor for cardiovascular (CV) diseases. In addition, several studies indicate that MetS correlates with the increased risk of cancer in adults. The mechanisms linking MetS and cancer are not fully understood. Several risk factors involved in MetS are also cancer risk factors, such as the consumption of high calorie-food or high fat intake, low fibre intake, and sedentary lifestyle. Other common aspects of both cancer and MetS are oxidative stress and inflammation. In addition, some anticancer treatments can induce cardiotoxicity, including, for instance, left ventricular (LV) dysfunction and heart failure (HF), endothelial dysfunction and hypertension. In this review, we analyse several aspects of MetS, cancer and cardiotoxicity from anticancer drugs. In particular, we focus on oxidative stress in ageing, cancer and CV diseases, and we analyse the connections among CV risk factors, cancer and cardiotoxicity from anticancer drugs.
KW - Ageing
KW - Cancer
KW - Cardiovascular disease
KW - Cardiovascular toxicity from anticancer drugs
KW - Metabolic syndrome
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U2 - 10.3390/antiox9070641
DO - 10.3390/antiox9070641
M3 - Review article
AN - SCOPUS:85088241718
VL - 9
SP - 1
EP - 20
JO - Antioxidants
JF - Antioxidants
SN - 2076-3921
IS - 7
M1 - 641
ER -