Abstract
Reporting in this issue of Developmental Cell, L'honoré etal. (2014) show that a network composed of Pitx2/Pitx3 and downstream antioxidant enzymes protects differentiating skeletal muscle from excessive reactive oxygen species production during fetal myogenesis. Genetic deficiency of Pitx2/Pitx3 results in irreversible oxidative DNA damage and apoptosis, impairing skeletal muscle development.
Original language | English |
---|---|
Pages (from-to) | 373-374 |
Number of pages | 2 |
Journal | Developmental Cell |
Volume | 29 |
Issue number | 4 |
DOIs | |
Publication status | Published - May 27 2014 |
ASJC Scopus subject areas
- Developmental Biology