Redox or death: Checking on fetal myogenesis

Lucia Latella, Pier Lorenzo Puri

Research output: Contribution to journalArticlepeer-review

Abstract

Reporting in this issue of Developmental Cell, L'honoré etal. (2014) show that a network composed of Pitx2/Pitx3 and downstream antioxidant enzymes protects differentiating skeletal muscle from excessive reactive oxygen species production during fetal myogenesis. Genetic deficiency of Pitx2/Pitx3 results in irreversible oxidative DNA damage and apoptosis, impairing skeletal muscle development.

Original languageEnglish
Pages (from-to)373-374
Number of pages2
JournalDevelopmental Cell
Volume29
Issue number4
DOIs
Publication statusPublished - May 27 2014

ASJC Scopus subject areas

  • Developmental Biology

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