Redox or death: Checking on fetal myogenesis

Lucia Latella; Pier Lorenzo Puri

doi:10.1016/j.devcel.2014.05.005

Redox or death: Checking on fetal myogenesis

Lucia Latella, Pier Lorenzo Puri

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Reporting in this issue of Developmental Cell, L'honoré etal. (2014) show that a network composed of Pitx2/Pitx3 and downstream antioxidant enzymes protects differentiating skeletal muscle from excessive reactive oxygen species production during fetal myogenesis. Genetic deficiency of Pitx2/Pitx3 results in irreversible oxidative DNA damage and apoptosis, impairing skeletal muscle development.

Original language	English
Pages (from-to)	373-374
Number of pages	2
Journal	Developmental Cell
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.devcel.2014.05.005
Publication status	Published - May 27 2014

ASJC Scopus subject areas

Developmental Biology

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title = "Redox or death: Checking on fetal myogenesis",

abstract = "Reporting in this issue of Developmental Cell, L'honor{\'e} etal. (2014) show that a network composed of Pitx2/Pitx3 and downstream antioxidant enzymes protects differentiating skeletal muscle from excessive reactive oxygen species production during fetal myogenesis. Genetic deficiency of Pitx2/Pitx3 results in irreversible oxidative DNA damage and apoptosis, impairing skeletal muscle development.",

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