TY - JOUR
T1 - Reduced activity of cortico-striatal fibres in the R6/2 mouse model of Huntington's disease
AU - Traficante, Anna
AU - Riozzi, Barbara
AU - Cannella, Milena
AU - Rampello, Liborio
AU - Squitieri, Ferdinando
AU - Battaglia, Giuseppe
PY - 2007/12
Y1 - 2007/12
N2 - We have used the R6/2 mice to study cortico-striatal glutamatergic transmission by microdialysis in freely moving mice. Basal extracellular striatal glutamate concentrations were lower in R6/2 mice at 12 weeks of age, but not at 6 weeks of age, when neurological symptoms start to develop. In contrast, K-induced glutamate release was blunted in the striatum of R6/2 mice at both 6 and 12 weeks of age as compared with age-matched controls. We also found a substantial reduction in striatal pro-BDNF (brain derived neurotrophic factor) levels associated with no changes in the mature form of BDNF, as assessed by immunoblotting, in 12-week-old R6/2 mice, suggesting a reduced turnover rate of BDNF in the striatum of these mice. These data support the hypothesis of a cortico-striatal dysfunction in Huntington's disease.
AB - We have used the R6/2 mice to study cortico-striatal glutamatergic transmission by microdialysis in freely moving mice. Basal extracellular striatal glutamate concentrations were lower in R6/2 mice at 12 weeks of age, but not at 6 weeks of age, when neurological symptoms start to develop. In contrast, K-induced glutamate release was blunted in the striatum of R6/2 mice at both 6 and 12 weeks of age as compared with age-matched controls. We also found a substantial reduction in striatal pro-BDNF (brain derived neurotrophic factor) levels associated with no changes in the mature form of BDNF, as assessed by immunoblotting, in 12-week-old R6/2 mice, suggesting a reduced turnover rate of BDNF in the striatum of these mice. These data support the hypothesis of a cortico-striatal dysfunction in Huntington's disease.
KW - BDNF
KW - Glutamate
KW - Huntington's disease
KW - Microdialysis
KW - R6/2 mouse
KW - Striatum
UR - http://www.scopus.com/inward/record.url?scp=36248951526&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36248951526&partnerID=8YFLogxK
U2 - 10.1097/WNR.0b013e3282f262ca
DO - 10.1097/WNR.0b013e3282f262ca
M3 - Article
C2 - 18007201
AN - SCOPUS:36248951526
VL - 18
SP - 1997
EP - 2000
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 18
ER -