Reduced activity of cortico-striatal fibres in the R6/2 mouse model of Huntington's disease

Anna Traficante, Barbara Riozzi, Milena Cannella, Liborio Rampello, Ferdinando Squitieri, Giuseppe Battaglia

Research output: Contribution to journalArticlepeer-review

Abstract

We have used the R6/2 mice to study cortico-striatal glutamatergic transmission by microdialysis in freely moving mice. Basal extracellular striatal glutamate concentrations were lower in R6/2 mice at 12 weeks of age, but not at 6 weeks of age, when neurological symptoms start to develop. In contrast, K-induced glutamate release was blunted in the striatum of R6/2 mice at both 6 and 12 weeks of age as compared with age-matched controls. We also found a substantial reduction in striatal pro-BDNF (brain derived neurotrophic factor) levels associated with no changes in the mature form of BDNF, as assessed by immunoblotting, in 12-week-old R6/2 mice, suggesting a reduced turnover rate of BDNF in the striatum of these mice. These data support the hypothesis of a cortico-striatal dysfunction in Huntington's disease.

Original languageEnglish
Pages (from-to)1997-2000
Number of pages4
JournalNeuroReport
Volume18
Issue number18
DOIs
Publication statusPublished - Dec 2007

Keywords

  • BDNF
  • Glutamate
  • Huntington's disease
  • Microdialysis
  • R6/2 mouse
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Reduced activity of cortico-striatal fibres in the R6/2 mouse model of Huntington's disease'. Together they form a unique fingerprint.

Cite this