Reduced aerobic metabolic efficiency in postischemic myocardium dysfunction in rats: Role of aging

P. Abete, A. Cioppa, P. Ferrara, P. Caccese, N. Ferrara, F. Rengo

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

It has been suggested that aging may enhance the deleterious effects of myocardial ischemia-reperfusion. This study evaluates the relationship between oxygen consumption and functional impairment during reperfusion following myocardial ischemia in adult and senescent rat hearts. Global ischemia induced a marked impairment of contractile function which was significantly higher in senescent than in adult hearts. During reperfusion postischemic dysfunction was more evident in senescent hearts: At the 10th minute, the developed pressure recovered less (p <0.05) and end-diastolic pressure increased more (p <0.05) in senescent than in adult hearts. However, oxygen consumption per unit of work was significantly higher throughout 60 min of reperfusion when compared to controls with no significant difference between adult and senescent hearts. This study demonstrates that following ischemia and reperfusion depression of function and inappropriately high oxygen consumption were observed in both adult and senescent hearts. However, aging was associated with greater con-tractile impairment, which occurred in the absence of further deterioration of metabolic efficiency of contraction.

Original languageEnglish
Pages (from-to)187-194
Number of pages8
JournalGerontology
Volume41
Issue number4
DOIs
Publication statusPublished - 1995

Fingerprint

Myocardium
Reperfusion
Oxygen Consumption
Myocardial Ischemia
Ischemia
Myocardial Reperfusion
Blood Pressure
Pressure

Keywords

  • Ischemia
  • Oxygen consumption
  • Reperfusion

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Abete, P., Cioppa, A., Ferrara, P., Caccese, P., Ferrara, N., & Rengo, F. (1995). Reduced aerobic metabolic efficiency in postischemic myocardium dysfunction in rats: Role of aging. Gerontology, 41(4), 187-194. https://doi.org/10.1159/000213681

Reduced aerobic metabolic efficiency in postischemic myocardium dysfunction in rats : Role of aging. / Abete, P.; Cioppa, A.; Ferrara, P.; Caccese, P.; Ferrara, N.; Rengo, F.

In: Gerontology, Vol. 41, No. 4, 1995, p. 187-194.

Research output: Contribution to journalArticle

Abete, P, Cioppa, A, Ferrara, P, Caccese, P, Ferrara, N & Rengo, F 1995, 'Reduced aerobic metabolic efficiency in postischemic myocardium dysfunction in rats: Role of aging', Gerontology, vol. 41, no. 4, pp. 187-194. https://doi.org/10.1159/000213681
Abete, P. ; Cioppa, A. ; Ferrara, P. ; Caccese, P. ; Ferrara, N. ; Rengo, F. / Reduced aerobic metabolic efficiency in postischemic myocardium dysfunction in rats : Role of aging. In: Gerontology. 1995 ; Vol. 41, No. 4. pp. 187-194.
@article{12105debece140b6ab82916a17394bb5,
title = "Reduced aerobic metabolic efficiency in postischemic myocardium dysfunction in rats: Role of aging",
abstract = "It has been suggested that aging may enhance the deleterious effects of myocardial ischemia-reperfusion. This study evaluates the relationship between oxygen consumption and functional impairment during reperfusion following myocardial ischemia in adult and senescent rat hearts. Global ischemia induced a marked impairment of contractile function which was significantly higher in senescent than in adult hearts. During reperfusion postischemic dysfunction was more evident in senescent hearts: At the 10th minute, the developed pressure recovered less (p <0.05) and end-diastolic pressure increased more (p <0.05) in senescent than in adult hearts. However, oxygen consumption per unit of work was significantly higher throughout 60 min of reperfusion when compared to controls with no significant difference between adult and senescent hearts. This study demonstrates that following ischemia and reperfusion depression of function and inappropriately high oxygen consumption were observed in both adult and senescent hearts. However, aging was associated with greater con-tractile impairment, which occurred in the absence of further deterioration of metabolic efficiency of contraction.",
keywords = "Ischemia, Oxygen consumption, Reperfusion",
author = "P. Abete and A. Cioppa and P. Ferrara and P. Caccese and N. Ferrara and F. Rengo",
year = "1995",
doi = "10.1159/000213681",
language = "English",
volume = "41",
pages = "187--194",
journal = "Gerontology",
issn = "0304-324X",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Reduced aerobic metabolic efficiency in postischemic myocardium dysfunction in rats

T2 - Role of aging

AU - Abete, P.

AU - Cioppa, A.

AU - Ferrara, P.

AU - Caccese, P.

AU - Ferrara, N.

AU - Rengo, F.

PY - 1995

Y1 - 1995

N2 - It has been suggested that aging may enhance the deleterious effects of myocardial ischemia-reperfusion. This study evaluates the relationship between oxygen consumption and functional impairment during reperfusion following myocardial ischemia in adult and senescent rat hearts. Global ischemia induced a marked impairment of contractile function which was significantly higher in senescent than in adult hearts. During reperfusion postischemic dysfunction was more evident in senescent hearts: At the 10th minute, the developed pressure recovered less (p <0.05) and end-diastolic pressure increased more (p <0.05) in senescent than in adult hearts. However, oxygen consumption per unit of work was significantly higher throughout 60 min of reperfusion when compared to controls with no significant difference between adult and senescent hearts. This study demonstrates that following ischemia and reperfusion depression of function and inappropriately high oxygen consumption were observed in both adult and senescent hearts. However, aging was associated with greater con-tractile impairment, which occurred in the absence of further deterioration of metabolic efficiency of contraction.

AB - It has been suggested that aging may enhance the deleterious effects of myocardial ischemia-reperfusion. This study evaluates the relationship between oxygen consumption and functional impairment during reperfusion following myocardial ischemia in adult and senescent rat hearts. Global ischemia induced a marked impairment of contractile function which was significantly higher in senescent than in adult hearts. During reperfusion postischemic dysfunction was more evident in senescent hearts: At the 10th minute, the developed pressure recovered less (p <0.05) and end-diastolic pressure increased more (p <0.05) in senescent than in adult hearts. However, oxygen consumption per unit of work was significantly higher throughout 60 min of reperfusion when compared to controls with no significant difference between adult and senescent hearts. This study demonstrates that following ischemia and reperfusion depression of function and inappropriately high oxygen consumption were observed in both adult and senescent hearts. However, aging was associated with greater con-tractile impairment, which occurred in the absence of further deterioration of metabolic efficiency of contraction.

KW - Ischemia

KW - Oxygen consumption

KW - Reperfusion

UR - http://www.scopus.com/inward/record.url?scp=0029005465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029005465&partnerID=8YFLogxK

U2 - 10.1159/000213681

DO - 10.1159/000213681

M3 - Article

C2 - 7557495

AN - SCOPUS:0029005465

VL - 41

SP - 187

EP - 194

JO - Gerontology

JF - Gerontology

SN - 0304-324X

IS - 4

ER -