Reduced allele specific annexin A5 mRNA levels in placentas carrying the M2/ANXA5 allele

A. Markoff, S. Gerdes, S. Feldner, N. Bogdanova, V. Gerke, E. Grandone

Research output: Contribution to journalArticle

Abstract

We aimed to trace the allele specific expression of ANXA5 mRNA in placentas carrying the M2 haplotype, conferring higher recurrent pregnancy loss risk, in order to verify directly the role of M2 in the relevant organ. The M2 allele in heterozygous placentas results in an average of 42% reduced ANXA5 mRNA levels as compared to the normal allele. Protein levels in these samples show considerable variations, impossible for statistical interpretation. The M2 allele of ANXA5 can be linked to reduced mRNA levels in heterozygous placentas and could result in more confined protein levels (lowered expression dynamics) of annexin A5.

Original languageEnglish
Pages (from-to)937-940
Number of pages4
JournalPlacenta
Volume31
Issue number10
DOIs
Publication statusPublished - Oct 2010

Keywords

  • Annexin A5
  • ANXA5
  • M2 haplotype
  • Placenta
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Developmental Biology

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