TY - JOUR
T1 - Reduced atherosclerotic burden in subjects with genetically determined low oxidative stress
AU - Violi, Francesco
AU - Pignatelli, Pasquale
AU - Pignata, Claudio
AU - Plebani, Alessandro
AU - Rossi, Paolo
AU - Sanguigni, Valerio
AU - Carnevale, Roberto
AU - Soresina, Annarosa
AU - Finocchi, Andrea
AU - Cirillo, Emilia
AU - Catasca, Elisa
AU - Angelico, Francesco
AU - Loffredo, Lorenzo
PY - 2013/2
Y1 - 2013/2
N2 - Objective-: NADPH oxidase, one of the most important enzymes producing reactive oxidant species, is suggested to play a role in experimental atherosclerosis, but its role in human atherosclerosis is still unclear. We hypothesized that a reduced activity of NADPH oxidase might be linked to a reduced atherosclerotic burden. METHODS AND RESULTS-: Thirty-one women carriers of hereditary deficiency of NOX2, the catalytic subunit of NADPH oxidase, were matched for sex and age with 31 controls and 31 obese women. Flow-mediated dilation and intima-media thickness, 2 surrogate markers of atherosclerosis, serum activity of NOX2, urinary isoprostanes, serum levels of nitrite/nitrate, and platelet production of isoprostanes and nitrite/nitrate were determined. Compared with controls (5.7±3.0% and 0.60±0.11 mm), carriers of NOX2 deficiency had higher flow-mediated dilation (9.2±5.0%; P
AB - Objective-: NADPH oxidase, one of the most important enzymes producing reactive oxidant species, is suggested to play a role in experimental atherosclerosis, but its role in human atherosclerosis is still unclear. We hypothesized that a reduced activity of NADPH oxidase might be linked to a reduced atherosclerotic burden. METHODS AND RESULTS-: Thirty-one women carriers of hereditary deficiency of NOX2, the catalytic subunit of NADPH oxidase, were matched for sex and age with 31 controls and 31 obese women. Flow-mediated dilation and intima-media thickness, 2 surrogate markers of atherosclerosis, serum activity of NOX2, urinary isoprostanes, serum levels of nitrite/nitrate, and platelet production of isoprostanes and nitrite/nitrate were determined. Compared with controls (5.7±3.0% and 0.60±0.11 mm), carriers of NOX2 deficiency had higher flow-mediated dilation (9.2±5.0%; P
KW - atherosclerosis
KW - NADPH oxidase
KW - oxidative stress
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U2 - 10.1161/ATVBAHA.112.300438
DO - 10.1161/ATVBAHA.112.300438
M3 - Article
C2 - 23288160
AN - SCOPUS:84872906530
VL - 33
SP - 406
EP - 412
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 2
ER -