Abstract
Objective-: NADPH oxidase, one of the most important enzymes producing reactive oxidant species, is suggested to play a role in experimental atherosclerosis, but its role in human atherosclerosis is still unclear. We hypothesized that a reduced activity of NADPH oxidase might be linked to a reduced atherosclerotic burden. METHODS AND RESULTS-: Thirty-one women carriers of hereditary deficiency of NOX2, the catalytic subunit of NADPH oxidase, were matched for sex and age with 31 controls and 31 obese women. Flow-mediated dilation and intima-media thickness, 2 surrogate markers of atherosclerosis, serum activity of NOX2, urinary isoprostanes, serum levels of nitrite/nitrate, and platelet production of isoprostanes and nitrite/nitrate were determined. Compared with controls (5.7±3.0% and 0.60±0.11 mm), carriers of NOX2 deficiency had higher flow-mediated dilation (9.2±5.0%; P
| Original language | English |
|---|---|
| Pages (from-to) | 406-412 |
| Number of pages | 7 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 33 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2013 |
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Keywords
- atherosclerosis
- NADPH oxidase
- oxidative stress
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Reduced atherosclerotic burden in subjects with genetically determined low oxidative stress. / Violi, Francesco; Pignatelli, Pasquale; Pignata, Claudio; Plebani, Alessandro; Rossi, Paolo; Sanguigni, Valerio; Carnevale, Roberto; Soresina, Annarosa; Finocchi, Andrea; Cirillo, Emilia; Catasca, Elisa; Angelico, Francesco; Loffredo, Lorenzo.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 33, No. 2, 02.2013, p. 406-412.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduced atherosclerotic burden in subjects with genetically determined low oxidative stress
AU - Violi, Francesco
AU - Pignatelli, Pasquale
AU - Pignata, Claudio
AU - Plebani, Alessandro
AU - Rossi, Paolo
AU - Sanguigni, Valerio
AU - Carnevale, Roberto
AU - Soresina, Annarosa
AU - Finocchi, Andrea
AU - Cirillo, Emilia
AU - Catasca, Elisa
AU - Angelico, Francesco
AU - Loffredo, Lorenzo
PY - 2013/2
Y1 - 2013/2
N2 - Objective-: NADPH oxidase, one of the most important enzymes producing reactive oxidant species, is suggested to play a role in experimental atherosclerosis, but its role in human atherosclerosis is still unclear. We hypothesized that a reduced activity of NADPH oxidase might be linked to a reduced atherosclerotic burden. METHODS AND RESULTS-: Thirty-one women carriers of hereditary deficiency of NOX2, the catalytic subunit of NADPH oxidase, were matched for sex and age with 31 controls and 31 obese women. Flow-mediated dilation and intima-media thickness, 2 surrogate markers of atherosclerosis, serum activity of NOX2, urinary isoprostanes, serum levels of nitrite/nitrate, and platelet production of isoprostanes and nitrite/nitrate were determined. Compared with controls (5.7±3.0% and 0.60±0.11 mm), carriers of NOX2 deficiency had higher flow-mediated dilation (9.2±5.0%; P
AB - Objective-: NADPH oxidase, one of the most important enzymes producing reactive oxidant species, is suggested to play a role in experimental atherosclerosis, but its role in human atherosclerosis is still unclear. We hypothesized that a reduced activity of NADPH oxidase might be linked to a reduced atherosclerotic burden. METHODS AND RESULTS-: Thirty-one women carriers of hereditary deficiency of NOX2, the catalytic subunit of NADPH oxidase, were matched for sex and age with 31 controls and 31 obese women. Flow-mediated dilation and intima-media thickness, 2 surrogate markers of atherosclerosis, serum activity of NOX2, urinary isoprostanes, serum levels of nitrite/nitrate, and platelet production of isoprostanes and nitrite/nitrate were determined. Compared with controls (5.7±3.0% and 0.60±0.11 mm), carriers of NOX2 deficiency had higher flow-mediated dilation (9.2±5.0%; P
KW - atherosclerosis
KW - NADPH oxidase
KW - oxidative stress
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UR - http://www.scopus.com/inward/citedby.url?scp=84872906530&partnerID=8YFLogxK
U2 - 10.1161/ATVBAHA.112.300438
DO - 10.1161/ATVBAHA.112.300438
M3 - Article
C2 - 23288160
AN - SCOPUS:84872906530
VL - 33
SP - 406
EP - 412
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 2
ER -