Reduced atherosclerotic burden in subjects with genetically determined low oxidative stress

Francesco Violi, Pasquale Pignatelli, Claudio Pignata, Alessandro Plebani, Paolo Rossi, Valerio Sanguigni, Roberto Carnevale, Annarosa Soresina, Andrea Finocchi, Emilia Cirillo, Elisa Catasca, Francesco Angelico, Lorenzo Loffredo

Research output: Contribution to journalArticlepeer-review


Objective-: NADPH oxidase, one of the most important enzymes producing reactive oxidant species, is suggested to play a role in experimental atherosclerosis, but its role in human atherosclerosis is still unclear. We hypothesized that a reduced activity of NADPH oxidase might be linked to a reduced atherosclerotic burden. METHODS AND RESULTS-: Thirty-one women carriers of hereditary deficiency of NOX2, the catalytic subunit of NADPH oxidase, were matched for sex and age with 31 controls and 31 obese women. Flow-mediated dilation and intima-media thickness, 2 surrogate markers of atherosclerosis, serum activity of NOX2, urinary isoprostanes, serum levels of nitrite/nitrate, and platelet production of isoprostanes and nitrite/nitrate were determined. Compared with controls (5.7±3.0% and 0.60±0.11 mm), carriers of NOX2 deficiency had higher flow-mediated dilation (9.2±5.0%; P

Original languageEnglish
Pages (from-to)406-412
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number2
Publication statusPublished - Feb 2013


  • atherosclerosis
  • NADPH oxidase
  • oxidative stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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