Reduced cardiac 123I-metaiodobenzylguanidine uptake in patients with spinocerebellar ataxia type 2: A comparative study with Parkinson's disease

Anna De Rosa, Sabina Pappatà, Teresa Pellegrino, Maria Fulvia De Leva, Gennaro Maddaluno, Giovanni Fiumara, Raffaella Carotenuto, Mario Petretta, Alessandro Filla, Giuseppe De Michele, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disorder characterized by cerebellar ataxia, supranuclear ophthalmoplegia, and peripheral neuropathy. Autonomic nervous system dysfunction is often present. This study evaluated the cardiac sympathetic function in patients with SCA2 using 123I-metaiodobenzylguanidine (MIBG) in comparison with patients with Parkinson's disease (PD) and control subjects. Methods: Nine patients with SCA2, nine patients with PD, and nine control subjects underwent 123I-MIBG imaging studies from which early and late heart-to-mediastinum (H/M) ratios and myocardial washout rates were calculated. Results: Early (F = 12.3, p <0.0001) and late (F = 16.8, p <0.0001) H/M ratios were significantly different among groups. In controls, early and late H/M ratios (2.2 ± 0.12 and 2.1 ± 0.20) were significantly higher than in patients with SCA2 (1.9 ± 0.23 and 1.8 ± 0.20, both p <0.05) and with patients with PD (1.7 ± 0.29 and 1.4 ± 0.35, both p <0.001). There was also a significant difference in washout rates among groups (F = 11.7, p <0.0001). In controls the washout rate (19.9 ± 9.6 %) was significantly lower (p <0.005) than in patients with PD (51.0 ± 23.7 %), but not different from that in SCA2 patients (19.5 ± 9.4 %). In SCA2 patients, in a multivariable linear regression analysis only the Scale for the Assessment and Rating of Ataxia score was independently associated with early H/M ratio (β = -0.12, p <0.05). Conclusion: 123I-MIBG myocardial scintigraphy demonstrated an impairment of cardiac sympathetic function in patients with SCA2, which was less marked than in PD patients. These results suggest that 123I-MIBG cardiac imaging could become a useful tool for analysing the pathophysiology of SCA2.

Original languageEnglish
Pages (from-to)1914-1921
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume40
Issue number12
DOIs
Publication statusPublished - 2013

Keywords

  • I-Metaiodobenzylguanidine
  • Cardiac sympathetic function
  • Spinocerebellar ataxia type 2

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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