Reduced collagenolytic activity of matrix metalloproteinases and development of liver fibrosis in the aging rat

Nicoletta Gagliano, Beatrice Arosio, Fabio Grizzi, Serge Masson, Jacopo Tagliabue, Nicola Dioguardi, Carlo Vergani, Giorgio Annoni

Research output: Contribution to journalArticlepeer-review

Abstract

Although moderate fibrosis is a histological hallmark of the aging liver, the molecular mechanisms underlying this phenomenon are little known. Here, we provide a comprehensive description of hepatic collagen expression and metabolism during natural aging in rats. Interstitial collagen accumulated significantly in the oldest animals, mainly in the periportal area (P

Original languageEnglish
Pages (from-to)413-425
Number of pages13
JournalMechanisms of Ageing and Development
Volume123
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • Aging
  • Fibrosis
  • Liver
  • Matrix metalloproteinases

ASJC Scopus subject areas

  • Ageing
  • Biochemistry
  • Developmental Biology
  • Developmental Neuroscience

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