Abstract
Although moderate fibrosis is a histological hallmark of the aging liver, the molecular mechanisms underlying this phenomenon are little known. Here, we provide a comprehensive description of hepatic collagen expression and metabolism during natural aging in rats. Interstitial collagen accumulated significantly in the oldest animals, mainly in the periportal area (P
Original language | English |
---|---|
Pages (from-to) | 413-425 |
Number of pages | 13 |
Journal | Mechanisms of Ageing and Development |
Volume | 123 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2002 |
Keywords
- Aging
- Fibrosis
- Liver
- Matrix metalloproteinases
ASJC Scopus subject areas
- Ageing
- Biochemistry
- Developmental Biology
- Developmental Neuroscience