Reduced collagenolytic activity of matrix metalloproteinases and development of liver fibrosis in the aging rat

Nicoletta Gagliano; Beatrice Arosio; Fabio Grizzi; Serge Masson; Jacopo Tagliabue; Nicola Dioguardi; Carlo Vergani; Giorgio Annoni

doi:10.1016/S0047-6374(01)00398-0

Reduced collagenolytic activity of matrix metalloproteinases and development of liver fibrosis in the aging rat

Nicoletta Gagliano, Beatrice Arosio, Fabio Grizzi, Serge Masson, Jacopo Tagliabue, Nicola Dioguardi, Carlo Vergani, Giorgio Annoni

Research output: Contribution to journal › Article › peer-review

Abstract

Although moderate fibrosis is a histological hallmark of the aging liver, the molecular mechanisms underlying this phenomenon are little known. Here, we provide a comprehensive description of hepatic collagen expression and metabolism during natural aging in rats. Interstitial collagen accumulated significantly in the oldest animals, mainly in the periportal area (P

Original language	English
Pages (from-to)	413-425
Number of pages	13
Journal	Mechanisms of Ageing and Development
Volume	123
Issue number	4
DOIs	https://doi.org/10.1016/S0047-6374(01)00398-0
Publication status	Published - 2002

Keywords

Aging
Fibrosis
Liver
Matrix metalloproteinases

ASJC Scopus subject areas

Ageing
Biochemistry
Developmental Biology
Developmental Neuroscience

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Reduced collagenolytic activity of matrix metalloproteinases and development of liver fibrosis in the aging rat. / Gagliano, Nicoletta; Arosio, Beatrice ; Grizzi, Fabio; Masson, Serge; Tagliabue, Jacopo; Dioguardi, Nicola; Vergani, Carlo; Annoni, Giorgio.

In: Mechanisms of Ageing and Development, Vol. 123, No. 4, 2002, p. 413-425.

Research output: Contribution to journal › Article › peer-review

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AU - Dioguardi, Nicola

AU - Vergani, Carlo

AU - Annoni, Giorgio

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