Reduced coronary flow reserve in patients with primary hyperparathyroidism: A study by G-SPECT myocardial perfusion imaging

Cecilia Marini, Massimo Giusti, Riccardo Armonino, Giorgio Ghigliotti, Gianpaolo Bezante, Lara Vera, Silvia Morbelli, Elena Pomposelli, Michela Massollo, Patrizia Gandolfo, Francesco Minuto, Gianmario Sambuceti

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The mechanisms underlying increased cardiovascular risk in primary hyperparathyroidism (pHPT) have not been fully defined. Recently, this issue has become the subject of renewed interest due to the increasing evidence that the endothelium and vascular wall are targets for parathyroid hormone (PTH). The aim of this study was to measure regional coronary flow reserve (CFR) to determine whether the vascular damage induced by pHPT extends to affect the coronary microvascular function. Methods: A total of 22 pHPT patients without a history of coronary artery disease and 7 age-matched control subjects were recruited. Dipyridamole myocardial blood flow (MBF) was assessed using 99mTc-sestamibi by measuring first-transit counts in the pulmonary artery and myocardial count rate from G-SPECT images. Baseline MBF was estimated 2 h later according to the same procedure. Regional CFR was defined as the ratio between dipyridamole and baseline MBF using a 17-segment left ventricular model. Results: Three pHPT patients showed reversible perfusion defects and were excluded from the analysis. In the remaining 19, CFR was significantly lower with respect to the control subjects (1.88±0.64 vs. 3.36±0.66, respectively; p

Original languageEnglish
Pages (from-to)2256-2263
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume37
Issue number12
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Coronary flow reserve
  • Coronary microcirculation
  • G-SPECT
  • Parathyroid hormone
  • Primary hyperparathyroidism

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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