Reduced coronary flow reserve in young adults with renal transplant

Sara Maria Viganò, Maurizio Turiel, Valentina Martina, Elisa Meregalli, Livio Tomasoni, Giuseppe De Blasio, Luigi Delfino, Alberto Edefonti, Paolo Grillo, Mirella Procaccio, Daniele Cusi, Luciana Ghio

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background. Some degree of cardiovascular disease should be suspected in young adults who have been paediatric renal transplant recipients also if no systematic data collection is routinely performed in clinical setting. The aim of our work was to evaluate the degree of cardiovascular damage in these young patients, using a minimally invasive technique. We then evaluated coronary flow reserve (CFR) and carotid intima-media thickness (IMT) in 25 patients (13 males, median age 23.7 years). Methods. Coronary flow velocity on the left anterior descending coronary artery was assessed by transthoracic echocardiography, before and after dipyridamole, after standard echocardiography. CFR was compared with that of a small control group (n = 16; median age 25 yrs). Results. In this relatively young sample, mean CFR was 2.8 ± 0.6 (median 2.75), and half of the patients had reduced coronary reserve (P = 0.01). Mean IMT (0.48 ± 0.08±mm) was only slightly, though significantly larger compared with the reference standard (P <0.05) but was significantly thinner in normotensive than in hypertensive patients (0.42 ± 0.06 vs 0.49 ± 0.05 mm, P <0.05). The time on dialysis prior to transplantation, hypertension and age at the time of CFR evaluation affect CFR. IMT did not correlate with CFR. Conclusions: CFR and IMT abnormalities are common in young transplant recipients, in spite of the fact that our paediatric population has much less of the atherosclerotic 'legacy' common to adult patients.

Original languageEnglish
Pages (from-to)2328-2333
Number of pages6
JournalNephrology Dialysis Transplantation
Volume22
Issue number8
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Young Adult
Transplants
Kidney
Echocardiography
Pediatrics
Carotid Intima-Media Thickness
Dipyridamole
Dialysis
Coronary Vessels
Cardiovascular Diseases
Transplantation
Hypertension
Control Groups
Population
Transplant Recipients

Keywords

  • Cardiovascular risk
  • Kidney transplantation
  • Paediatrics
  • Stress echography

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Reduced coronary flow reserve in young adults with renal transplant. / Viganò, Sara Maria; Turiel, Maurizio; Martina, Valentina; Meregalli, Elisa; Tomasoni, Livio; De Blasio, Giuseppe; Delfino, Luigi; Edefonti, Alberto; Grillo, Paolo; Procaccio, Mirella; Cusi, Daniele; Ghio, Luciana.

In: Nephrology Dialysis Transplantation, Vol. 22, No. 8, 08.2007, p. 2328-2333.

Research output: Contribution to journalArticle

Viganò, SM, Turiel, M, Martina, V, Meregalli, E, Tomasoni, L, De Blasio, G, Delfino, L, Edefonti, A, Grillo, P, Procaccio, M, Cusi, D & Ghio, L 2007, 'Reduced coronary flow reserve in young adults with renal transplant', Nephrology Dialysis Transplantation, vol. 22, no. 8, pp. 2328-2333. https://doi.org/10.1093/ndt/gfm110
Viganò, Sara Maria ; Turiel, Maurizio ; Martina, Valentina ; Meregalli, Elisa ; Tomasoni, Livio ; De Blasio, Giuseppe ; Delfino, Luigi ; Edefonti, Alberto ; Grillo, Paolo ; Procaccio, Mirella ; Cusi, Daniele ; Ghio, Luciana. / Reduced coronary flow reserve in young adults with renal transplant. In: Nephrology Dialysis Transplantation. 2007 ; Vol. 22, No. 8. pp. 2328-2333.
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AU - Viganò, Sara Maria

AU - Turiel, Maurizio

AU - Martina, Valentina

AU - Meregalli, Elisa

AU - Tomasoni, Livio

AU - De Blasio, Giuseppe

AU - Delfino, Luigi

AU - Edefonti, Alberto

AU - Grillo, Paolo

AU - Procaccio, Mirella

AU - Cusi, Daniele

AU - Ghio, Luciana

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N2 - Background. Some degree of cardiovascular disease should be suspected in young adults who have been paediatric renal transplant recipients also if no systematic data collection is routinely performed in clinical setting. The aim of our work was to evaluate the degree of cardiovascular damage in these young patients, using a minimally invasive technique. We then evaluated coronary flow reserve (CFR) and carotid intima-media thickness (IMT) in 25 patients (13 males, median age 23.7 years). Methods. Coronary flow velocity on the left anterior descending coronary artery was assessed by transthoracic echocardiography, before and after dipyridamole, after standard echocardiography. CFR was compared with that of a small control group (n = 16; median age 25 yrs). Results. In this relatively young sample, mean CFR was 2.8 ± 0.6 (median 2.75), and half of the patients had reduced coronary reserve (P = 0.01). Mean IMT (0.48 ± 0.08±mm) was only slightly, though significantly larger compared with the reference standard (P <0.05) but was significantly thinner in normotensive than in hypertensive patients (0.42 ± 0.06 vs 0.49 ± 0.05 mm, P <0.05). The time on dialysis prior to transplantation, hypertension and age at the time of CFR evaluation affect CFR. IMT did not correlate with CFR. Conclusions: CFR and IMT abnormalities are common in young transplant recipients, in spite of the fact that our paediatric population has much less of the atherosclerotic 'legacy' common to adult patients.

AB - Background. Some degree of cardiovascular disease should be suspected in young adults who have been paediatric renal transplant recipients also if no systematic data collection is routinely performed in clinical setting. The aim of our work was to evaluate the degree of cardiovascular damage in these young patients, using a minimally invasive technique. We then evaluated coronary flow reserve (CFR) and carotid intima-media thickness (IMT) in 25 patients (13 males, median age 23.7 years). Methods. Coronary flow velocity on the left anterior descending coronary artery was assessed by transthoracic echocardiography, before and after dipyridamole, after standard echocardiography. CFR was compared with that of a small control group (n = 16; median age 25 yrs). Results. In this relatively young sample, mean CFR was 2.8 ± 0.6 (median 2.75), and half of the patients had reduced coronary reserve (P = 0.01). Mean IMT (0.48 ± 0.08±mm) was only slightly, though significantly larger compared with the reference standard (P <0.05) but was significantly thinner in normotensive than in hypertensive patients (0.42 ± 0.06 vs 0.49 ± 0.05 mm, P <0.05). The time on dialysis prior to transplantation, hypertension and age at the time of CFR evaluation affect CFR. IMT did not correlate with CFR. Conclusions: CFR and IMT abnormalities are common in young transplant recipients, in spite of the fact that our paediatric population has much less of the atherosclerotic 'legacy' common to adult patients.

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