Reduced dopamine in peripheral blood lymphocytes in Parkinson's disease

Brunella Caronti, Gianluigi Tanda, Carlo Colosimo, Stefano Ruggieri, Caterina Calderaro, Guido Palladini, Francesco E. Pontieri, Gaetano Di Chiara

Research output: Contribution to journalArticle

Abstract

The early clinical symptoms of Parkinson's disease (PD) may be difficult to perceive and are frequently overlooked. Thus, interest has focused on the identification of biological or instrumental markers that may contribute to the early diagnosis of PD, with the aim of introducing neuroprotective therapies at the very start of illness. Impairment of nigrostriatal dopamine transmission can be visualized in vivo by functional imaging techniques, but these are rather complex and expensive examinations, available only in selected institutions. Here we show that dopamine content and tyrosine hydroxylase immunoreactivity are reduced in peripheral blood lymphocytes (PBL) in the early stages of PD. These data suggest that PBL may represent a simple and useful tool with which to identify precociously dopamine impairment in PD.

Original languageEnglish
Pages (from-to)2907-2910
Number of pages4
JournalNeuroReport
Volume10
Issue number14
Publication statusPublished - Sep 29 1999

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Keywords

  • Dopamine
  • Parkinson's disease
  • Peripheral blood lymphocytes
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Caronti, B., Tanda, G., Colosimo, C., Ruggieri, S., Calderaro, C., Palladini, G., Pontieri, F. E., & Di Chiara, G. (1999). Reduced dopamine in peripheral blood lymphocytes in Parkinson's disease. NeuroReport, 10(14), 2907-2910.