TY - JOUR
T1 - Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling
AU - Cilia, Roberto
AU - Ko, Ji Hyun
AU - Cho, Sang Soo
AU - van Eimeren, Thilo
AU - Marotta, Giorgio
AU - Pellecchia, Giovanna
AU - Pezzoli, Gianni
AU - Antonini, Angelo
AU - Strafella, Antonio P.
PY - 2010/7
Y1 - 2010/7
N2 - Pathological gambling (PG) represents a behavioral side effect of dopamine replacement therapy in a minority of patients with Parkinson's disease (PD). Using striatal dopamine transporter (DAT) with single photon emission tomography we assessed presynaptic dopaminergic function in 8 PD patients with PG, 21 matched PD control subjects, and 14 healthy subjects. Statistical Parametric Mapping was applied for image analysis. The analysis of variance (ANOVA) revealed that the three groups differed in dorsal and ventral striata bilaterally. The post-hoc analysis displayed a reduced tracer binding in the ventral striatum of PD patients with PG compared to PD controls, possibly reflecting either a reduction of mesolimbic projections or, alternatively, a lower membrane DAT expression on presynaptic terminals. The latter hypothesis is most likely given that the functional reduction of presynaptic reuptake would be more consistent with the increased dopamine levels in the ventral striatum recently reported in PD gamblers.
AB - Pathological gambling (PG) represents a behavioral side effect of dopamine replacement therapy in a minority of patients with Parkinson's disease (PD). Using striatal dopamine transporter (DAT) with single photon emission tomography we assessed presynaptic dopaminergic function in 8 PD patients with PG, 21 matched PD control subjects, and 14 healthy subjects. Statistical Parametric Mapping was applied for image analysis. The analysis of variance (ANOVA) revealed that the three groups differed in dorsal and ventral striata bilaterally. The post-hoc analysis displayed a reduced tracer binding in the ventral striatum of PD patients with PG compared to PD controls, possibly reflecting either a reduction of mesolimbic projections or, alternatively, a lower membrane DAT expression on presynaptic terminals. The latter hypothesis is most likely given that the functional reduction of presynaptic reuptake would be more consistent with the increased dopamine levels in the ventral striatum recently reported in PD gamblers.
KW - Addiction
KW - Dopamine transporter
KW - Impulse control disorders
KW - Neuroimaging
KW - Parkinson's disease
KW - Pathological gambling
KW - SPECT
KW - Statistical Parametric Mapping
KW - Ventral striatum
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U2 - 10.1016/j.nbd.2010.03.013
DO - 10.1016/j.nbd.2010.03.013
M3 - Article
C2 - 20338240
AN - SCOPUS:77952955623
VL - 39
SP - 98
EP - 104
JO - Neurobiology of Disease
JF - Neurobiology of Disease
SN - 0969-9961
IS - 1
ER -