Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling

Roberto Cilia, Ji Hyun Ko, Sang Soo Cho, Thilo van Eimeren, Giorgio Marotta, Giovanna Pellecchia, Gianni Pezzoli, Angelo Antonini, Antonio P. Strafella

Research output: Contribution to journalArticle

Abstract

Pathological gambling (PG) represents a behavioral side effect of dopamine replacement therapy in a minority of patients with Parkinson's disease (PD). Using striatal dopamine transporter (DAT) with single photon emission tomography we assessed presynaptic dopaminergic function in 8 PD patients with PG, 21 matched PD control subjects, and 14 healthy subjects. Statistical Parametric Mapping was applied for image analysis. The analysis of variance (ANOVA) revealed that the three groups differed in dorsal and ventral striata bilaterally. The post-hoc analysis displayed a reduced tracer binding in the ventral striatum of PD patients with PG compared to PD controls, possibly reflecting either a reduction of mesolimbic projections or, alternatively, a lower membrane DAT expression on presynaptic terminals. The latter hypothesis is most likely given that the functional reduction of presynaptic reuptake would be more consistent with the increased dopamine levels in the ventral striatum recently reported in PD gamblers.

Original languageEnglish
Pages (from-to)98-104
Number of pages7
JournalNeurobiology of Disease
Volume39
Issue number1
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Gambling
Dopamine Plasma Membrane Transport Proteins
Parkinson Disease
Dopamine
Corpus Striatum
Membrane Transport Proteins
Presynaptic Terminals
Photons
Analysis of Variance
Healthy Volunteers
Tomography
Ventral Striatum

Keywords

  • Addiction
  • Dopamine transporter
  • Impulse control disorders
  • Neuroimaging
  • Parkinson's disease
  • Pathological gambling
  • SPECT
  • Statistical Parametric Mapping
  • Ventral striatum

ASJC Scopus subject areas

  • Neurology

Cite this

Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling. / Cilia, Roberto; Ko, Ji Hyun; Cho, Sang Soo; van Eimeren, Thilo; Marotta, Giorgio; Pellecchia, Giovanna; Pezzoli, Gianni; Antonini, Angelo; Strafella, Antonio P.

In: Neurobiology of Disease, Vol. 39, No. 1, 07.2010, p. 98-104.

Research output: Contribution to journalArticle

Cilia, R, Ko, JH, Cho, SS, van Eimeren, T, Marotta, G, Pellecchia, G, Pezzoli, G, Antonini, A & Strafella, AP 2010, 'Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling', Neurobiology of Disease, vol. 39, no. 1, pp. 98-104. https://doi.org/10.1016/j.nbd.2010.03.013
Cilia, Roberto ; Ko, Ji Hyun ; Cho, Sang Soo ; van Eimeren, Thilo ; Marotta, Giorgio ; Pellecchia, Giovanna ; Pezzoli, Gianni ; Antonini, Angelo ; Strafella, Antonio P. / Reduced dopamine transporter density in the ventral striatum of patients with Parkinson's disease and pathological gambling. In: Neurobiology of Disease. 2010 ; Vol. 39, No. 1. pp. 98-104.
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