Reduced erythrocyte deformability and hypercoagulability in idiopathic sudden sensorineural hearing loss

Lucia Mannini, Rita Paniccia, Emanuele Cecchi, Agatina Alessandrello Liotta, Emanuela Leprini, Pasquale Berloco, Paolo Pagnini, Rosanna Abbate, Gian Franco Gensini, Domenico Prisco

Research output: Contribution to journalArticlepeer-review


Objective. Sudden sensorineural hearing loss is a frequent disease whose aetiology is still unknown in about 80% of patients. Aim of this study was to evaluate if haemorheological changes and some indexes of hypercoagulability and hypofibrinolysis are associated with idiopathic sudden sensorineural hearing loss (ISSHL). Methods. We studied 63 patients with ISSHL and 67 healthy control subjects, matched for age, sex and traditional cardiovascular risk factors. Haemorheological studies were performed by assessing whole blood viscosity (WBV) at 0.512 s-1 and 94.5 s-1, plasma viscosity (PLV) and erythrocyte deformability index (DI). To assess whole blood coagulation Sonoclot analysis was performed. Sonoclot variables studied were Sonoclot activated clotting time (SonACT), clot rate and time to peak. Fibrinogen, PAI-1 antigen (ag) and factor VIII:C plasma levels were also measured. Results. WBV, PLV, SonACT, clot rate, time to peak, PAI-1ag and factor VIII:C were significantly altered in patients in comparison with controls (p-1, DI, SonACT, clot rate, PAI-1ag plasma levels and factor VIII:C activity were independently associated with ISSHL (p

Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalClinical Hemorheology and Microcirculation
Issue number1
Publication statusPublished - 2005


  • Factor VIII:C
  • Hypercoagulability
  • Hyperviscosity
  • PAI-1
  • Sudden deafness

ASJC Scopus subject areas

  • Hematology
  • Physiology


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