Reduced free protein S levels in patients with inflammatory bowel disease: Prevalence, clinical relevance, and role of anti-protein S antibodies

S. Saibeni, M. Vecchi, C. Valsecchi, E. M. Faioni, C. Razzari, R. De Franchis

Research output: Contribution to journalArticle

Abstract

We evaluated free plasma levels of protein S, a natural anticoagulant factor, the prevalence of anti-protein S antibodies, a possible cause of protein S deficiency, and their correlation with anti-phospholipid antibodies in 53 patients with inflammatory bowel disease (IBD) and 53 age- and sex-matched controls. Mean free plasma protein S levels (± SD) were significantly lower in IBD patients (0.98 ± 0.32 IU/ml) than in controls (1.06 ± 0.28 IU/ml) (P <0.05); only one patient showed protein S deficiency. Specific antibodies to protein S were found in four IBD patients (7.5%) and in one control (1.9%) (P = NS). Five IBD patients (9.4%) and none of the controls showed anti-phospholipid antibodies (P <0.06). No correlation was found between free protein S levels and anti-protein S antibodies or between anti-protein S and anti-phospholipid antibodies. In conclusion, free plasma protein S levels are slightly but significantly decreased in IBD patients. The prevalence of anti-protein S and antiphospholipid antibodies is increased in IBD patients. Anti-protein S antibodies do not appear to determine low protein S levels or to overlap with or belong to anti-phospholipid antibodies.

Original languageEnglish
Pages (from-to)637-643
Number of pages7
JournalDigestive Diseases and Sciences
Volume46
Issue number3
DOIs
Publication statusPublished - 2001

Keywords

  • Antibodies
  • Inflammatory bowel disease
  • Protein S
  • Thrombosis

ASJC Scopus subject areas

  • Gastroenterology

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