Abstract
Background: Chronic inflammatory conditions, such as psoriasis, may pose an increased risk of cancer due to impaired immunosurveillance resulting from chronic inflammation and immunosuppressive medications. Objectives: To compare the risk of non-melanoma skin cancer (NMSC) in a retrospective cohort of 72,739 psoriasis patients and 25,956 non-dermatological patients. Materials & methods: A record linkage was performed for data on hospitalizations, and the occurrence of NMSC was compared by computing the relative risk (RR) and modelled using multiple logistic regression. Results: Overall, the occurrence of NMSC was 9.6‰ (95% CI: 8.9-10.3‰) in psoriasis patients and 19.6‰ (95% CI: 18.0-21.4‰) in non-dermatological patients (RR = 0.49; 95% CI: 0.44-0.55). The simultaneous adjustment for gender, age, and phototherapy yielded a RR of 0.84 (95% CI: 0.75-0.95). With regards to phototherapy, the occurrence of NMSC was significantly higher among psoriasis patients who underwent phototherapy relative to those who did not (27.0‰ vs. 9.3‰). Conclusions: In this large retrospective study, we found that patients with psoriasis had a 16% lower probability of having NMSC when compared to a group of non-dermatological patients. Further studies, preferably with a prospective longitudinal design to collect more precise data, are needed to corroborate our findings.
| Original language | English |
|---|---|
| Pages (from-to) | 359-362 |
| Number of pages | 4 |
| Journal | European Journal of Dermatology |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
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Keywords
- Non-melanoma skin cancer
- Phototherapy
- Psoriasis
ASJC Scopus subject areas
- Dermatology
Cite this
Reduced frequency of non-melanoma skin cancer in 72,739 patients with psoriasis : A retrospective study. / Paradisi, Andrea; Didona, Biagio; Tabolli, Stefano; Ricci, Francesco; Sobrino, Luciano; Panebianco, Annarita; Abeni, Damiano.
In: European Journal of Dermatology, Vol. 27, No. 4, 01.01.2017, p. 359-362.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduced frequency of non-melanoma skin cancer in 72,739 patients with psoriasis
T2 - A retrospective study
AU - Paradisi, Andrea
AU - Didona, Biagio
AU - Tabolli, Stefano
AU - Ricci, Francesco
AU - Sobrino, Luciano
AU - Panebianco, Annarita
AU - Abeni, Damiano
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background: Chronic inflammatory conditions, such as psoriasis, may pose an increased risk of cancer due to impaired immunosurveillance resulting from chronic inflammation and immunosuppressive medications. Objectives: To compare the risk of non-melanoma skin cancer (NMSC) in a retrospective cohort of 72,739 psoriasis patients and 25,956 non-dermatological patients. Materials & methods: A record linkage was performed for data on hospitalizations, and the occurrence of NMSC was compared by computing the relative risk (RR) and modelled using multiple logistic regression. Results: Overall, the occurrence of NMSC was 9.6‰ (95% CI: 8.9-10.3‰) in psoriasis patients and 19.6‰ (95% CI: 18.0-21.4‰) in non-dermatological patients (RR = 0.49; 95% CI: 0.44-0.55). The simultaneous adjustment for gender, age, and phototherapy yielded a RR of 0.84 (95% CI: 0.75-0.95). With regards to phototherapy, the occurrence of NMSC was significantly higher among psoriasis patients who underwent phototherapy relative to those who did not (27.0‰ vs. 9.3‰). Conclusions: In this large retrospective study, we found that patients with psoriasis had a 16% lower probability of having NMSC when compared to a group of non-dermatological patients. Further studies, preferably with a prospective longitudinal design to collect more precise data, are needed to corroborate our findings.
AB - Background: Chronic inflammatory conditions, such as psoriasis, may pose an increased risk of cancer due to impaired immunosurveillance resulting from chronic inflammation and immunosuppressive medications. Objectives: To compare the risk of non-melanoma skin cancer (NMSC) in a retrospective cohort of 72,739 psoriasis patients and 25,956 non-dermatological patients. Materials & methods: A record linkage was performed for data on hospitalizations, and the occurrence of NMSC was compared by computing the relative risk (RR) and modelled using multiple logistic regression. Results: Overall, the occurrence of NMSC was 9.6‰ (95% CI: 8.9-10.3‰) in psoriasis patients and 19.6‰ (95% CI: 18.0-21.4‰) in non-dermatological patients (RR = 0.49; 95% CI: 0.44-0.55). The simultaneous adjustment for gender, age, and phototherapy yielded a RR of 0.84 (95% CI: 0.75-0.95). With regards to phototherapy, the occurrence of NMSC was significantly higher among psoriasis patients who underwent phototherapy relative to those who did not (27.0‰ vs. 9.3‰). Conclusions: In this large retrospective study, we found that patients with psoriasis had a 16% lower probability of having NMSC when compared to a group of non-dermatological patients. Further studies, preferably with a prospective longitudinal design to collect more precise data, are needed to corroborate our findings.
KW - Non-melanoma skin cancer
KW - Phototherapy
KW - Psoriasis
UR - http://www.scopus.com/inward/record.url?scp=85028972780&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028972780&partnerID=8YFLogxK
U2 - 10.1684/ejd.2017.3032
DO - 10.1684/ejd.2017.3032
M3 - Article
AN - SCOPUS:85028972780
VL - 27
SP - 359
EP - 362
JO - European Journal of Dermatology
JF - European Journal of Dermatology
SN - 1167-1122
IS - 4
ER -