Reduced integrity of sensorimotor projections traversing the posterior limb of the internal capsule in children with congenital hemiparesis

Henry Tsao, Kerstin Pannek, Simona Fiori, Roslyn N. Boyd, Stephen Rose

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

There is reduced integrity of corticospinal projections that traverse the posterior limb of the internal capsule (PLIC) in children with unilateral cerebral palsy (CP). It remains unclear whether there are changes in integrity of other projections traversing the PLIC. Forty children with congenital hemiparesis and 15 typically developing children underwent structural and diffusion-weighted MRI. All children with congenital hemiparesis showed lesions to the periventricular white matter. Structural images were parcellated into 34 cortical regions per hemisphere and posterior limb of the internal capsule was identified. PLIC connections to each cortical region were extracted using probabilistic tractography. Differences between hemispheres for each cortical projection (asymmetry index (AI)) and tract microstructure (fractional anisotropy (FA), mean diffusivity (MD)) were assessed. The results showed that 17 children (42.5%) with congenital hemiparesis showed bilateral lesions on structural MRI. Projections to the primary motor cortex (precentral gyrus and paracentral lobule) showed greater asymmetry in unilateral CP group compared to typically developing children and indicate reduced projections on the hemisphere contralateral to the impaired limb (i.e., contralateral hemisphere). Reduced FA and increased MD were also observed for connections with the primary motor cortex, primary sensory cortex (postcentral gyrus) and precuneus on the contralateral hemisphere in children with congenital hemiparesis. Similar changes were observed between children with unilateral and bilateral lesions on structural MRI. Notably, microstructural changes were associated with deficits in both sensory and motor function. The findings further unravel the underlying neuroanatomical correlates of sensorimotor deficits in children with congenital hemiparesis.

Original languageEnglish
Pages (from-to)250-260
Number of pages11
JournalResearch in Developmental Disabilities
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 2014

Fingerprint

Internal Capsule
Paresis
Extremities
Anisotropy
Motor Cortex
Cerebral Palsy
Parietal Lobe
Diffusion Magnetic Resonance Imaging
Somatosensory Cortex
Frontal Lobe

Keywords

  • Cerebral palsy
  • Congenital hemiparesis
  • Diffusion-weighted MRI
  • Posterior limb of the internal capsule
  • Sensorimotor function

ASJC Scopus subject areas

  • Clinical Psychology
  • Developmental and Educational Psychology

Cite this

Reduced integrity of sensorimotor projections traversing the posterior limb of the internal capsule in children with congenital hemiparesis. / Tsao, Henry; Pannek, Kerstin; Fiori, Simona; Boyd, Roslyn N.; Rose, Stephen.

In: Research in Developmental Disabilities, Vol. 35, No. 2, 02.2014, p. 250-260.

Research output: Contribution to journalArticle

Tsao, Henry ; Pannek, Kerstin ; Fiori, Simona ; Boyd, Roslyn N. ; Rose, Stephen. / Reduced integrity of sensorimotor projections traversing the posterior limb of the internal capsule in children with congenital hemiparesis. In: Research in Developmental Disabilities. 2014 ; Vol. 35, No. 2. pp. 250-260.
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