Reduced intensity allogeneic stem cell transplantation for follicular lymphoma relapsing after an autologous transplant achieves durable long-term disease control: An analysis from the lymphoma working party of the EBMT

S. P. Robinson, A. Boumendil, H. Finel, H. Schouten, G. Ehninger, J. Maertens, C. Crawley, A. Rambaldi, N. Russell, W. Anders, D. Blaise, I. Yakoub-Agha, A. Ganser, L. Castagna, L. Volin, J. Y. Cahn, S. Montoto, P. Dreger

Research output: Contribution to journalArticle

Abstract

Background: Patients with follicular lymphoma (FL) relapsing after an autologous transplant (autoSCT) may be treated with a variety of therapies, including a reduced intensity allogeneic transplant (RICalloSCT). We conducted a retrospective analysis of a large cohort of patients undergoing RICalloSCT for FL in this setting. Patients and methods: A total of 183 patients, median age 45 years (range 21-69), had undergone an autoSCT at a median of 30 months before the RICalloSCT. Before the RICalloSCT, they had received a median of four lines (range 3-10) of therapy and 81% of patients had chemosensitive disease and 16% had chemoresistant disease. Grafts were donated from sibling (47%) or unrelated donors (53%). Results: With a median follow-up of 59 months, the non-relapse mortality (NRM) was 27% at 2 years. The median remission duration post-autoSCT and RICalloSCT was 14 and 43 months, respectively. The 5-year relapse/progression rate, progression-free survival and overall survival were 16%, 48% and 51%, respectively, and were associated with age and disease status at RICalloSCT. Conclusion: These data suggest that an RICalloSCT is an effective salvage strategy in patients with FL recurring after a prior autoSCT and might overcome the poor prognostic impact of early relapse after autoSCT.

Original languageEnglish
Article numbermdw124
Pages (from-to)1088-1094
Number of pages7
JournalAnnals of Oncology
Volume27
Issue number6
DOIs
Publication statusPublished - Jun 18 2016

Keywords

  • Follicular lymphoma
  • Reduced intensity allogeneic stem cell transplant

ASJC Scopus subject areas

  • Oncology
  • Hematology

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    Robinson, S. P., Boumendil, A., Finel, H., Schouten, H., Ehninger, G., Maertens, J., Crawley, C., Rambaldi, A., Russell, N., Anders, W., Blaise, D., Yakoub-Agha, I., Ganser, A., Castagna, L., Volin, L., Cahn, J. Y., Montoto, S., & Dreger, P. (2016). Reduced intensity allogeneic stem cell transplantation for follicular lymphoma relapsing after an autologous transplant achieves durable long-term disease control: An analysis from the lymphoma working party of the EBMT. Annals of Oncology, 27(6), 1088-1094. [mdw124]. https://doi.org/10.1093/annonc/mdw124