Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia

Davide Soligo, Marina Motta, Chiara Borsotti, Adalberto Ibatici, Agostino Cortelezzi, Giorgio Lambertenghí Deliliers

Research output: Contribution to journalArticle

Abstract

We report the preliminary results of 12 patients with advanced stage chronic lymphocytic leukemia (CLL) transplanted following reduced intensity conditioning (RIC. With a median of 22 months of follow-up, 9 patients are alive and 3 have died of progressive disease, graft-versus-host disease (GVHD) or toxic hepatitis. Acute grade I-III GVHD occurred in 33% of patients and chronic GVHD in 50%. Eight of the 12 patients achieved a complete remission (CR) and 2 patients a partial remission (PR). Donor lymphocyte infusion was effective in 6 patients. Event-free survival, progression-free survival and non-relapse mortality at 3 years were 68%, 42% and 16%, respectively. Our results show successful immunomodulation and reduction in tumor burden in high risk CLL.

Original languageEnglish
Pages (from-to)885-886
Number of pages2
JournalHaematologica
Volume89
Issue number7
Publication statusPublished - Jul 2004

    Fingerprint

Keywords

  • Allogeneic
  • Chronic lymphocytic leukemia
  • Reduced-intensity
  • Transplantation

ASJC Scopus subject areas

  • Hematology

Cite this

Soligo, D., Motta, M., Borsotti, C., Ibatici, A., Cortelezzi, A., & Deliliers, G. L. (2004). Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia. Haematologica, 89(7), 885-886.