Abstract
We report the preliminary results of 12 patients with advanced stage chronic lymphocytic leukemia (CLL) transplanted following reduced intensity conditioning (RIC. With a median of 22 months of follow-up, 9 patients are alive and 3 have died of progressive disease, graft-versus-host disease (GVHD) or toxic hepatitis. Acute grade I-III GVHD occurred in 33% of patients and chronic GVHD in 50%. Eight of the 12 patients achieved a complete remission (CR) and 2 patients a partial remission (PR). Donor lymphocyte infusion was effective in 6 patients. Event-free survival, progression-free survival and non-relapse mortality at 3 years were 68%, 42% and 16%, respectively. Our results show successful immunomodulation and reduction in tumor burden in high risk CLL.
| Original language | English |
|---|---|
| Pages (from-to) | 885-886 |
| Number of pages | 2 |
| Journal | Haematologica |
| Volume | 89 |
| Issue number | 7 |
| Publication status | Published - Jul 2004 |
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Keywords
- Allogeneic
- Chronic lymphocytic leukemia
- Reduced-intensity
- Transplantation
ASJC Scopus subject areas
- Hematology
Cite this
Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia. / Soligo, Davide; Motta, Marina; Borsotti, Chiara; Ibatici, Adalberto; Cortelezzi, Agostino; Deliliers, Giorgio Lambertenghí.
In: Haematologica, Vol. 89, No. 7, 07.2004, p. 885-886.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia
AU - Soligo, Davide
AU - Motta, Marina
AU - Borsotti, Chiara
AU - Ibatici, Adalberto
AU - Cortelezzi, Agostino
AU - Deliliers, Giorgio Lambertenghí
PY - 2004/7
Y1 - 2004/7
N2 - We report the preliminary results of 12 patients with advanced stage chronic lymphocytic leukemia (CLL) transplanted following reduced intensity conditioning (RIC. With a median of 22 months of follow-up, 9 patients are alive and 3 have died of progressive disease, graft-versus-host disease (GVHD) or toxic hepatitis. Acute grade I-III GVHD occurred in 33% of patients and chronic GVHD in 50%. Eight of the 12 patients achieved a complete remission (CR) and 2 patients a partial remission (PR). Donor lymphocyte infusion was effective in 6 patients. Event-free survival, progression-free survival and non-relapse mortality at 3 years were 68%, 42% and 16%, respectively. Our results show successful immunomodulation and reduction in tumor burden in high risk CLL.
AB - We report the preliminary results of 12 patients with advanced stage chronic lymphocytic leukemia (CLL) transplanted following reduced intensity conditioning (RIC. With a median of 22 months of follow-up, 9 patients are alive and 3 have died of progressive disease, graft-versus-host disease (GVHD) or toxic hepatitis. Acute grade I-III GVHD occurred in 33% of patients and chronic GVHD in 50%. Eight of the 12 patients achieved a complete remission (CR) and 2 patients a partial remission (PR). Donor lymphocyte infusion was effective in 6 patients. Event-free survival, progression-free survival and non-relapse mortality at 3 years were 68%, 42% and 16%, respectively. Our results show successful immunomodulation and reduction in tumor burden in high risk CLL.
KW - Allogeneic
KW - Chronic lymphocytic leukemia
KW - Reduced-intensity
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=3242761511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3242761511&partnerID=8YFLogxK
M3 - Article
C2 - 15257953
AN - SCOPUS:3242761511
VL - 89
SP - 885
EP - 886
JO - Haematologica
JF - Haematologica
SN - 0390-6078
IS - 7
ER -