Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia

Davide Soligo, Marina Motta, Chiara Borsotti, Adalberto Ibatici, Agostino Cortelezzi, Giorgio Lambertenghí Deliliers

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report the preliminary results of 12 patients with advanced stage chronic lymphocytic leukemia (CLL) transplanted following reduced intensity conditioning (RIC. With a median of 22 months of follow-up, 9 patients are alive and 3 have died of progressive disease, graft-versus-host disease (GVHD) or toxic hepatitis. Acute grade I-III GVHD occurred in 33% of patients and chronic GVHD in 50%. Eight of the 12 patients achieved a complete remission (CR) and 2 patients a partial remission (PR). Donor lymphocyte infusion was effective in 6 patients. Event-free survival, progression-free survival and non-relapse mortality at 3 years were 68%, 42% and 16%, respectively. Our results show successful immunomodulation and reduction in tumor burden in high risk CLL.

Original languageEnglish
Pages (from-to)885-886
Number of pages2
JournalHaematologica
Volume89
Issue number7
Publication statusPublished - Jul 2004

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B-Cell Chronic Lymphocytic Leukemia
Transplants
Graft vs Host Disease
Disease-Free Survival
Chemical and Drug Induced Liver Injury
Immunomodulation
Tumor Burden
Tissue Donors
Lymphocytes
Mortality

Keywords

  • Allogeneic
  • Chronic lymphocytic leukemia
  • Reduced-intensity
  • Transplantation

ASJC Scopus subject areas

  • Hematology

Cite this

Soligo, D., Motta, M., Borsotti, C., Ibatici, A., Cortelezzi, A., & Deliliers, G. L. (2004). Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia. Haematologica, 89(7), 885-886.

Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia. / Soligo, Davide; Motta, Marina; Borsotti, Chiara; Ibatici, Adalberto; Cortelezzi, Agostino; Deliliers, Giorgio Lambertenghí.

In: Haematologica, Vol. 89, No. 7, 07.2004, p. 885-886.

Research output: Contribution to journalArticle

Soligo, D, Motta, M, Borsotti, C, Ibatici, A, Cortelezzi, A & Deliliers, GL 2004, 'Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia', Haematologica, vol. 89, no. 7, pp. 885-886.
Soligo D, Motta M, Borsotti C, Ibatici A, Cortelezzi A, Deliliers GL. Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia. Haematologica. 2004 Jul;89(7):885-886.
Soligo, Davide ; Motta, Marina ; Borsotti, Chiara ; Ibatici, Adalberto ; Cortelezzi, Agostino ; Deliliers, Giorgio Lambertenghí. / Reduced intensity conditioning allogeneic transplant for advanced chronic lymphocytic leukemia. In: Haematologica. 2004 ; Vol. 89, No. 7. pp. 885-886.
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