Reduced intrahepatic fat content is associated with increased whole-body lipid oxidation in patients with type 1 diabetes

G. Perseghin, G. Lattuada, F. De Cobelli, A. Esposito, F. Costantino, T. Canu, P. Scifo, F. De Taddeo, P. Maffi, A. Secchi, A. Del Maschio, L. Luzi

Research output: Contribution to journalArticlepeer-review

Abstract

Aims/hypothesis: Insulin resistance may be associated with ectopic fat accumulation potentially determined by reduced lipid oxidation. In patients with type 1 diabetes peripheral insulin resistance is associated with higher intramyocellular lipid content. We assessed whether these patients are also characterised by intrahepatic fat accumulation and abnormal fat oxidation. Methods: Nineteen patients with type 1 diabetes (6 women, 13 men, age 35±7 years, BMI 23±3 kg/m 2, HbA 1c 8.7±1.4%) and 19 healthy matched individuals were studied by (1) euglycaemic-hyperinsulinaemic clamp combined with [6,6- 2H 2]glucose infusion to assess whole-body glucose metabolism; (2) indirect calorimetry to assess glucose and lipid oxidation; and (3) localised 1H-magnetic resonance spectroscopy of the liver to assess intrahepatic fat content. Results: Patients with type 1 diabetes showed a reduced insulin-stimulated metabolic clearance rate of glucose (4.3±1.3 ml kg -1 min -1) in comparison with normal subjects (6.0±1.6 ml kg -1 min -1; p-1 min -1; p

Original languageEnglish
Pages (from-to)2615-2621
Number of pages7
JournalDiabetologia
Volume48
Issue number12
DOIs
Publication statusPublished - Dec 2005

Keywords

  • Ectopic fat
  • Insulin resistance
  • Intrahepatic fat content
  • Lipid oxidation
  • Magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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