Reduced levels of adiponectin in sleep apnea syndrome

B. Masserini, P. S. Morpurgo, F. Donadio, C. Baldessari, P. Beck-Peccoz, E. Orsi

Research output: Contribution to journalArticle

Abstract

Background: To investigate adiponectin levels in an obese population with and without obstructive sleep apnea syndrome (OSAS) and the acute modifications in adiponectin after a whole-night control by auto continuous positive air pressure (CPAP). Methods: 46 obese subjects [22 males, 24 females, age 55.1±11.4 yr, body mass index (BIVII) 38.9±6.5 kg/m2]: 11 OSAS with apnea/hypopnea index (AHI) from 10/h to 30/h, 14 OSAS with AHI >30/h and 21 without OSAS. Thirty-seven normal weight healthy subjects (20 males, 17 females, age 31.3±9.5 yr, BMI 21.5±1.8 kg/m2). Serum adiponectin levels, biochemical parameters, anthropometric measurements, pulmonary function, pulse-oxymetry and polisomnography. Results: The 3 groups of obese patients were comparable for gender, BMI, age, fat mass, fatfree mass, hip and waist circumference, waist-to-hip ratio (WHR), systolic and diastolic blood pressure and glycometabolic parameters. Adiponectin levels were significantly reduced in obese patients compared to healthy normal weight subjects (8.1±3.5 vs 11.3±4.8 μg/ml p

Original languageEnglish
Pages (from-to)700-705
Number of pages6
JournalJournal of Endocrinological Investigation
Volume29
Issue number8
Publication statusPublished - Sep 2006

Keywords

  • Adiponectin
  • Apnea hypopnea index
  • Insulin resistance
  • Obesity
  • Sleep apnea syndrome

ASJC Scopus subject areas

  • Endocrinology

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    Masserini, B., Morpurgo, P. S., Donadio, F., Baldessari, C., Beck-Peccoz, P., & Orsi, E. (2006). Reduced levels of adiponectin in sleep apnea syndrome. Journal of Endocrinological Investigation, 29(8), 700-705.