Reduced Lysosomal Acid Lipase Activity in Adult Patients With Non-alcoholic Fatty Liver Disease

Francesco Baratta, Daniele Pastori, Maria Del Ben, Licia Polimeni, Giancarlo Labbadia, Serena Di Santo, Fiorella Piemonte, Giulia Tozzi, Francesco Violi, Francesco Angelico

Research output: Contribution to journalArticle

Abstract

Non-alcoholic fatty liver disease (NAFLD) is characterized by intra-hepatic fat accumulation and mechanisms involved in its pathogenesis are not fully explained. Lysosomal Acid Lipase (LAL) is a key enzyme in lipid metabolism. We investigated its activity in patients with fatty liver.LAL activity (nmol/spot/h) was measured in 100 adult healthy subjects (HS) and in 240 NAFLD patients. A sub-analysis on 35 patients with biopsy-proven non-alcoholic steatohepatitis (NASH) was performed.Median LAL activity was 1.15 (0.95-1.72) in HS. It was significantly reduced in NAFLD [0.78 (0.61-1.01), p <0.001 vs. HS]. A further reduction was observed in the subgroup of NASH [0.67 (0.51-0.77), p <0.001 vs HS]. Patients with LAL activity below median had higher values of serum total cholesterol (p

Original languageEnglish
Pages (from-to)750-754
Number of pages5
JournalEBioMedicine
Volume2
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

Keywords

  • Lysosomal acid lipase
  • Metabolic syndrome
  • Non-alcoholic fatty liver disease
  • Non-alcoholic steatohepatitis
  • Statins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Baratta, F., Pastori, D., Del Ben, M., Polimeni, L., Labbadia, G., Di Santo, S., Piemonte, F., Tozzi, G., Violi, F., & Angelico, F. (2015). Reduced Lysosomal Acid Lipase Activity in Adult Patients With Non-alcoholic Fatty Liver Disease. EBioMedicine, 2(7), 750-754. https://doi.org/10.1016/j.ebiom.2015.05.018