Reduced memory B cells in patients with hyper IgE syndrome

C. Speckmann, A. Enders, C. Woellner, D. Thiel, A. Rensing-Ehl, M. Schlesier, J. Rohr, T. Jakob, E. Oswald, M. V. Kopp, O. Sanal, J. Litzman, A. Plebani, M. C. Pietrogrande, J. L. Franco, T. Espanol, B. Grimbacher, S. Ehl

Research output: Contribution to journalArticle

Abstract

Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.

Original languageEnglish
Pages (from-to)448-454
Number of pages7
JournalClinical Immunology
Volume129
Issue number3
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Atopic dermatitis
  • B cells
  • Hyper IgE syndrome
  • Memory cells
  • STAT-3

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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    Speckmann, C., Enders, A., Woellner, C., Thiel, D., Rensing-Ehl, A., Schlesier, M., Rohr, J., Jakob, T., Oswald, E., Kopp, M. V., Sanal, O., Litzman, J., Plebani, A., Pietrogrande, M. C., Franco, J. L., Espanol, T., Grimbacher, B., & Ehl, S. (2008). Reduced memory B cells in patients with hyper IgE syndrome. Clinical Immunology, 129(3), 448-454. https://doi.org/10.1016/j.clim.2008.08.002