TY - JOUR
T1 - Reduced mortality risk by a polyphenol-rich diet
T2 - An analysis from the Moli-sani study
AU - MOLI-SANI investigators
AU - Pounis, George
AU - Costanzo, Simona
AU - Spinelli, Maria
AU - Di Castelnuovo, Augusto
AU - de Curtis, Amalia
AU - Ruggiero, Emilia
AU - Persichillo, Mariarosaria
AU - Cerletti, Chiara
AU - Donati, Maria Benedetta
AU - de Gaetano, Giovanni
AU - Iacoviello, Licia
AU - Vermylen, Jos
AU - De Paula Carrasco, Ignacio
AU - Giampaoli, Simona
AU - Spagnuolo, Antonio
AU - Assanelli, Deodato
AU - Centritto, Vincenzo
AU - Spagnuolo, Pasquale
AU - Staniscia, Dante
AU - Bonanni, Americo
AU - Lorenzet, Roberto
AU - Mascioli, Antonio
AU - Olivieri, Marco
AU - Rotilio, Domenico
AU - Gianfagna, Francesco
AU - Giacci, Maurizio
AU - Padulo, Antonella
AU - Petraroia, Dario
AU - Magnacca, Sara
AU - Marracino, Federico
AU - Spinelli, Maria
AU - Silvestri, Christian
AU - dell'Elba, Giuseppe
AU - Grippi, Claudio
AU - De Lucia, Francesca
AU - Vohnout, Branislav
AU - Verna, Angelita
AU - Di Lillo, Maura
AU - Di Stefano, Irene
AU - Pampuch, Agnieszka
AU - Pannichella, Agostino
AU - Vizzarri, Antonio Rinaldo
AU - Barbato, Daniela
AU - Bracone, Francesca
AU - Di Giorgio, Carmine
AU - Panebianco, Simona
AU - Cugino, Daniela
AU - Ferri, Alessandra
AU - Mignogna, Marcella
AU - Santimone, Iolanda
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Objectives: The effect of the polyphenol content of the human diet on mortality risk is not yet fully understood. The aim of this study was to evaluate the association of a polyphenol-rich diet with mortality rate and a possible mediation effect by inflammation, in what we believe to be a novel, holistic approach. Methods: We analyzed 21 302 participants (10 980 women and 10 322 men, aged ≥35 y) from the Moli-sani cohort. The participants were followed up for a median of 8.3 y. The European Prospective Investigation into Cancer and Nutrition food frequency questionnaire (FFQ) was used for dietary assessment. Flavonol, flavone, flavanone, flavanol, anthocyanin, isoflavone, and lignan intakes were calculated using European Food Information Resource—Bioactive Substances in Food Information Systems and the polyphenol antioxidant content (PAC)-score was constructed to assess the total content of these nutrients in the diet. Results: Participants included in the highest quintile of intake of various polyphenol classes and subclasses presented a significant lower all-cause mortality risk compared with those in the lowest group of consumption (hazard ratio [HR] < 1; P < 0.05). Cox regression analyses adjusted for potential confounders indicated that participants in higher quintiles of PAC-score had lower all-cause mortality risk (HR <1; P < 0.05). When cause-specific mortality rates were considered, similar effects were observed for cardiocerebrovascular and cancer mortality (HR <1; P < 0.05). Conclusions: The polyphenol content of the diet was associated with reduced mortality risk in a Mediterranean population, possibly through an antiinflammatory mechanism.
AB - Objectives: The effect of the polyphenol content of the human diet on mortality risk is not yet fully understood. The aim of this study was to evaluate the association of a polyphenol-rich diet with mortality rate and a possible mediation effect by inflammation, in what we believe to be a novel, holistic approach. Methods: We analyzed 21 302 participants (10 980 women and 10 322 men, aged ≥35 y) from the Moli-sani cohort. The participants were followed up for a median of 8.3 y. The European Prospective Investigation into Cancer and Nutrition food frequency questionnaire (FFQ) was used for dietary assessment. Flavonol, flavone, flavanone, flavanol, anthocyanin, isoflavone, and lignan intakes were calculated using European Food Information Resource—Bioactive Substances in Food Information Systems and the polyphenol antioxidant content (PAC)-score was constructed to assess the total content of these nutrients in the diet. Results: Participants included in the highest quintile of intake of various polyphenol classes and subclasses presented a significant lower all-cause mortality risk compared with those in the lowest group of consumption (hazard ratio [HR] < 1; P < 0.05). Cox regression analyses adjusted for potential confounders indicated that participants in higher quintiles of PAC-score had lower all-cause mortality risk (HR <1; P < 0.05). When cause-specific mortality rates were considered, similar effects were observed for cardiocerebrovascular and cancer mortality (HR <1; P < 0.05). Conclusions: The polyphenol content of the diet was associated with reduced mortality risk in a Mediterranean population, possibly through an antiinflammatory mechanism.
KW - Flavonoid
KW - Inflammation
KW - Lignan
KW - Mortality
KW - Polyphenol
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UR - http://www.scopus.com/inward/citedby.url?scp=85044852448&partnerID=8YFLogxK
U2 - 10.1016/j.nut.2017.11.012
DO - 10.1016/j.nut.2017.11.012
M3 - Article
AN - SCOPUS:85044852448
VL - 48
SP - 87
EP - 95
JO - Nutrition International
JF - Nutrition International
SN - 0899-9007
ER -