Reduced NGF level and TrkA protein and TrkA gene expression in the optic nerve of rats with experimentally induced glaucoma

Valentina Sposato, Massimo Gilberto Bucci, Marco Coassin, Matteo Antonio Russo, Alessandro Lambiase, Luigi Aloe

Research output: Contribution to journalArticle

Abstract

Glaucoma (GL) is an optic neuropathy characterized by progressive loss of visual field due to retinal cell death and optic nerve (ON) degeneration, usually in response to abnormal elevated intraocular pressure (EIOP). It has previously demonstrated that cells of the ON express nerve growth factor (NGF) and NGF-receptors. Relatively little is known, however, about their role on the ON of the glaucomatous eye. The aim of the study was to elucidate this aspect. Using a rat model of GL we investigated the response of NGF and NGF-receptors in the ON of subjects with experimentally induced EIOP. Our results show that EIOP significantly impairs the presence of NGF and NGF-receptor proteins and TrkA gene expression in the ON of glaucomatous eye. These findings suggest that NGF and NGF-receptor might be important signals for the ON response in the EIOP.

Original languageEnglish
Pages (from-to)20-24
Number of pages5
JournalNeuroscience Letters
Volume446
Issue number1
DOIs
Publication statusPublished - Nov 28 2008

Keywords

  • Intraocular pressure (IOP)
  • Neurotrophins
  • NGF-receptor (NGFR)
  • Retinal ganglion cell (RGC)

ASJC Scopus subject areas

  • Neuroscience(all)

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