Reduced nocturnal fall in blood pressure, assessed by two ambulatory blood pressure monitorings and cardiac alterations in early phases of untreated essential hypertension

C. Cuspidi, I. Michev, S. Meani, B. Severgnini, V. Fusi, C. Corti, M. Salerno, C. Valerio, F. Magrini, A. Zanchetti

Research output: Contribution to journalArticle

Abstract

To investigate whether in recently diagnosed essential hypertensives a reduced nocturnal fall in blood pressure (BP), established on the basis of two 24-h ambulatory blood pressure monitorings (ABPM) is related to a greater cardiovascular damage. In all, 355 consecutive, recently diagnosed, never-treated essential hypertensives referred for the first time to our outpatient clinic were included in the study. Each patient underwent the following procedures: (1) two 24-h ABPMs performed within 3 weeks, (2) 24-h urinary collection for microalbuminuria, (3) nonmydriatic photography of ocular fundi, (4) echocardiography, (5) carotid ultrasonography. We defined nondipping profile as a night-day systolic and diastolic fall ≤ 10 % (mean of two ABPMs). A dipper BP profile was found in 238 patients, whereas in 117 patients a nondipper profile was present. The two groups were similar for age, gender, body mass index, smoking habit, clinic BP, 48-h BP and heart rate, while, by definition, night-time systolic and diastolic BP were significantly higher in nondippers than in dippers (130/81 vs 121/74 mmHg, P2 in both genders; (b) LVMI ≥134 gm2 in men and ≥110 in women; (c) LVMI ≥ 125 g/m2 in men and ≥ 110 g/m2 in women; (d) LVMI ≥ 51 g/m2.7 in men and ≥ 47 g/m2.7 in women was significantly higher in nondippers than in dippers (a: 12 vs 7%, P

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalJournal of Human Hypertension
Volume17
Issue number4
DOIs
Publication statusPublished - Apr 1 2003

Keywords

  • Ambulatory blood pressure monitoring
  • Cardiac structure
  • Nondippers

ASJC Scopus subject areas

  • Internal Medicine

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