Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia

Gary Donohoe, Thomas Frodl, Derek Morris, Ilaria Spoletini, Dara M. Cannon, Andrea Cherubini, Carlo Caltagirone, Paola Bossù, Colm McDonald, Michael Gill, Aiden P. Corvin, Gianfranco Spalletta

Research output: Contribution to journalArticle

Abstract

A three-marker C-A-T dysbindin haplotype identified by Williams et al (PMID: 15066891) is associated with increased risk for schizophrenia, decreased mRNA expression, poorer cognitive performance, and early sensory processing deficits. We investigated whether this same dysbindin risk haplotype was also associated with structural variation in the gray matter volume (GMV). Using voxel-based morphometry, whole-volume analysis revealed significantly reduced GMVs in both the right dorsolateral prefrontal and left occipital cortex, corresponding to the behavioral findings of impaired spatial working memory and EEG findings of impaired visual processing already reported. These data provide important evidence of the influence of dysbindin risk variants on brain structure, and suggest a possible mechanism by which disease risk is being increased.

Original languageEnglish
Pages (from-to)368-373
Number of pages6
JournalNeuropsychopharmacology
Volume35
Issue number2
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Dysbindin
  • MRI
  • Schizophrenia
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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    Donohoe, G., Frodl, T., Morris, D., Spoletini, I., Cannon, D. M., Cherubini, A., Caltagirone, C., Bossù, P., McDonald, C., Gill, M., Corvin, A. P., & Spalletta, G. (2010). Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia. Neuropsychopharmacology, 35(2), 368-373. https://doi.org/10.1038/npp.2009.140