Reduced peripheral skeletal muscle mass and abnormal reflex physiology in chronic heart failure

Massimo F. Piepoli, Agnieszka Kaczmarek, Darrel P. Francis, L. Ceri Davies, Mathias Rauchhaus, Ewa A. Jankowska, Stefan D. Anker, Alessandro Capucci, Waldemar Banasiak, Piotr Ponikowski

Research output: Contribution to journalArticle

Abstract

BACKGROUND - The muscle hypothesis implicates abnormalities in peripheral muscle as a source for the stimulus to the symptoms and reflex abnormalities seen in chronic heart failure (CHF). We investigated the relationship between skeletal muscle mass (with dual-energy x-ray absorptiometry) and activation of the ergoreflex (a peripheral reflex originating in skeletal muscle sensitive to products of muscle work) in CHF patients and whether this rapport is affected by the progression of the syndrome. METHODS AND RESULTS - We assessed 107 consecutive CHF patients (mean age, 61.9±10.9 years; 95% male; 25 cachectics) and 24 age-matched normal subjects (mean age, 59.0±11.1 years; 91% male). Compared with normal subjects, patients had a higher ergoreflex (in ventilation, 6.2±.6.1 versus 0.6±0.6 L/min; P

Original languageEnglish
Pages (from-to)126-134
Number of pages9
JournalCirculation
Volume114
Issue number2
DOIs
Publication statusPublished - Jul 2006

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Keywords

  • Heart failure
  • Nervous system
  • Receptors
  • Reflex
  • Ventilation

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Piepoli, M. F., Kaczmarek, A., Francis, D. P., Davies, L. C., Rauchhaus, M., Jankowska, E. A., Anker, S. D., Capucci, A., Banasiak, W., & Ponikowski, P. (2006). Reduced peripheral skeletal muscle mass and abnormal reflex physiology in chronic heart failure. Circulation, 114(2), 126-134. https://doi.org/10.1161/CIRCULATIONAHA.105.605980